Title:
COMPOSITION HAVING ANTIVIRAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/158602
Kind Code:
A1
Abstract:
The present invention provides a composition which has strong antiviral activity against COVID-19 and can be used in drugs, food products, and hygiene products. The present invention provides a composition having antiviral activity, and contains, as an active ingredient, at least one compound selected from the group consisting of the compounds represented in formula (I) below, or a derivative thereof. (In the formula, R16 is either crosslinked with R13, forming an ether bond or a thioether bond, or is hydrogen, halogen, a hydroxy group, a thiol group, or a substituted or unsubstituted acyloxy group having a carbon number of 1 to 3, or a substituted or unsubstituted, saturated or unsaturated hydrocarbon group having a carbon number of 1 to 4, or a substituted or unsubstituted alkoxy group having a carbon number of 1 to 4; R1 to R7, R15, and R17 to R20 are each hydrogen, halogen, a hydroxy group, a thiol group, or a substituted or unsubstituted acyloxy group having a carbon number of 1 to 3, or a substituted or unsubstituted, saturated or unsaturated hydrocarbon group having a carbon number of 1 to 4, or a substituted or unsubstituted alkoxy group having a carbon number of 1 to 4; R14 is either crosslinked with R8, forming a disulfide bond, or is hydrogen; R13 is either crosslinked with R16, forming an ether bond or a thioether bond, or is crosslinked with R8, forming a disulfide bond; R9 and R12 are each either hydrogen or substituted or unsubstituted alkoxy groups having a carbon number of 1 to 3; R10 and R11 are each either oxygen or sulfur; and R8 is crosslinked with R13 or R14, forming a disulfide bond.)
Inventors:
WATANABE KENJI (JP)
TSUNEMATSU YUTA (JP)
TSUNEMATSU YUTA (JP)
Application Number:
PCT/JP2022/002563
Publication Date:
July 28, 2022
Filing Date:
January 25, 2022
Export Citation:
Assignee:
ADENOPREVENT CO LTD (JP)
SHIZUOKA PREFECTURE PUBLIC UNIV CORPORATION (JP)
SHIZUOKA PREFECTURE PUBLIC UNIV CORPORATION (JP)
International Classes:
A61K31/548; A01N43/90; A61K31/499; A61K31/554; A61P31/14
Other References:
YUTA TSUNEMATSU; NAOYA MAEDA; MAMORU YOKOYAMA; PRANATCHAREEYA CHANKHAMJON; KENJI WATANABE; KIRSTIN SCHERLACH; CHRISTIAN HERTWECK: "Enzymatic Amide Tailoring Promotes Retro‐Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine", ANGEWANDTE CHEMIE, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 130, no. 43, 24 September 2018 (2018-09-24), DE , pages 14247 - 14250, XP071375461, ISSN: 0044-8249, DOI: 10.1002/ange.201806740
YURCHENKO ANTON NIKOLAEVICH, BERDYSHEV DMITRY V., SMETANINA OLGA F., IVANETS ELENA V., ZHURAVLEVA OLESYA I., RASIN ANTON B., KHUDY: "Citriperazines A-D produced by a marine algae-derived fungus Penicillium sp. KMM 4672", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, vol. 34, no. 8, 17 April 2020 (2020-04-17), GB , pages 1118 - 1123, XP009538466, ISSN: 1478-6419, DOI: 10.1080/14786419.2018.1552696
QUIMQUE MARK TRISTAN J., NOTARTE KIN ISRAEL R., FERNANDEZ REY ARTURO T., MENDOZA MARK ANDREW O., LIMAN RHENZ ALFRED D., LIM JUSTIN: "Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 39, no. 12, 13 August 2021 (2021-08-13), US , pages 4316 - 4333, XP055953088, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1776639
ANONYMOUS: "Development and Utilization of Immunity Activation Ingredients", FOOD PROCESSING AND INGREDIENTS, vol. 55, no. 10, 1 January 2020 (2020-01-01), JP , pages 31 - 38, XP009538476, ISSN: 0911-3932
YURCHENKO ANTON NIKOLAEVICH, BERDYSHEV DMITRY V., SMETANINA OLGA F., IVANETS ELENA V., ZHURAVLEVA OLESYA I., RASIN ANTON B., KHUDY: "Citriperazines A-D produced by a marine algae-derived fungus Penicillium sp. KMM 4672", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, vol. 34, no. 8, 17 April 2020 (2020-04-17), GB , pages 1118 - 1123, XP009538466, ISSN: 1478-6419, DOI: 10.1080/14786419.2018.1552696
QUIMQUE MARK TRISTAN J., NOTARTE KIN ISRAEL R., FERNANDEZ REY ARTURO T., MENDOZA MARK ANDREW O., LIMAN RHENZ ALFRED D., LIM JUSTIN: "Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 39, no. 12, 13 August 2021 (2021-08-13), US , pages 4316 - 4333, XP055953088, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1776639
ANONYMOUS: "Development and Utilization of Immunity Activation Ingredients", FOOD PROCESSING AND INGREDIENTS, vol. 55, no. 10, 1 January 2020 (2020-01-01), JP , pages 31 - 38, XP009538476, ISSN: 0911-3932
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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