Title:
COMPOSITION HAVING ULTRA-HIGH SENSITIVITY AND HIGH SELECTIVITY FOR DETECTING COPPER ION AND FLUORESCENT CHEMICAL SENSOR
Document Type and Number:
WIPO Patent Application WO/2014/200164
Kind Code:
A1
Abstract:
The present invention relates to a composition having ultra-high sensitivity and high selectivity for detecting a copper ion; a fluorescent chemical sensor comprising the same; a method for manufacturing the same; a method for selectively detecting a copper ion; a method for screening a copper ion chelating agent; and a method for confirming a chelating effect of a copper ion chelating agent. The present invention is applicable in detecting a copper ion in water from a river, lake, ocean, or the like, and bio-samples, such as plasma, serum, and urine, and is applicable in high-rate mass-screening for evaluating the effect of the existing copper ion chelating agent and developing novel copper ion chelating agents. Further, the copper ion can be qualitatively and quantitatively detected in the serum in cells and in the body, and the present invention is applicable as a disease diagnosing kit.
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Inventors:
PARK KYEONG SOON (KR)
LEE AE JU (KR)
LEE AE JU (KR)
Application Number:
PCT/KR2013/010418
Publication Date:
December 18, 2014
Filing Date:
November 15, 2013
Export Citation:
Assignee:
KOREA BASIC SCIENCE INST (KR)
International Classes:
C09K11/00; G01N21/64; G01N33/52
Other References:
LEE, AE JU ET AL.: "A novel near-infrared fluorescence chemosensor for copper ion detection using click ligation and energy transfer.", CHEMICAL COMMUNICATIONS, vol. 49, May 2013 (2013-05-01), pages 5969 - 5971
XU, QINGLING ET AL.: "Visual detection of copper ions based on azide- and alkyne-functionalized polydiacetylene vesicles.", JOURNAL OF MATERIALS CHEMISTRY, vol. 21, 2011, pages 15214 - 15217
WOLFBEIS, OTTO S. ET AL.: "The click reaction in the luminescent probing of metal ions, and its implications on biolabeling techniques.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION., vol. 46, no. 17, 2007, pages 2980 - 2982
SHEN, QINPENG ET AL.: "A simple ''clickable'' biosensor for colorimetric detection of copper(II) ions based on unmodified gold nanoparticles.", BIOSENSORS AND BIOELECTRONICS., vol. 41, May 2013 (2013-05-01), pages 663 - 668
YUAN, LIN ET AL.: "Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging.", CHEMICAL SOCIETY REVIEWS, vol. 42, January 2013 (2013-01-01), pages 622 - 661
XU, QINGLING ET AL.: "Visual detection of copper ions based on azide- and alkyne-functionalized polydiacetylene vesicles.", JOURNAL OF MATERIALS CHEMISTRY, vol. 21, 2011, pages 15214 - 15217
WOLFBEIS, OTTO S. ET AL.: "The click reaction in the luminescent probing of metal ions, and its implications on biolabeling techniques.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION., vol. 46, no. 17, 2007, pages 2980 - 2982
SHEN, QINPENG ET AL.: "A simple ''clickable'' biosensor for colorimetric detection of copper(II) ions based on unmodified gold nanoparticles.", BIOSENSORS AND BIOELECTRONICS., vol. 41, May 2013 (2013-05-01), pages 663 - 668
YUAN, LIN ET AL.: "Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging.", CHEMICAL SOCIETY REVIEWS, vol. 42, January 2013 (2013-01-01), pages 622 - 661
Attorney, Agent or Firm:
YANG, Boo-Hyun (Chungdong Building1659-2 Inhundong,,Gwanak-gu, Seoul 151-832, KR)
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