Title:
COMPOSITION FOR IMPROVING HEART FUNCTION
Document Type and Number:
WIPO Patent Application WO/2023/120704
Kind Code:
A1
Abstract:
The present disclosure provides a composition that is for improving a heart function and that contains a compound represented by formula (I), or an ester, oxide, prodrug, pharmaceutically acceptable salt or solvate thereof. Also provided is a composition that is for treating heart failure and that contains a compound represented by formula (I), or an ester, oxide, pharmaceutically acceptable salt or solvate thereof.
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Inventors:
KAKIZUKA AKIRA (JP)
ONO KOH (JP)
HORIE TAKAHIRO (JP)
TSUJI SHUHEI (JP)
WATANABE SHIN (JP)
OTANI CHIHARU (JP)
SOWA NAOYA (JP)
ONO KOH (JP)
HORIE TAKAHIRO (JP)
TSUJI SHUHEI (JP)
WATANABE SHIN (JP)
OTANI CHIHARU (JP)
SOWA NAOYA (JP)
Application Number:
PCT/JP2022/047636
Publication Date:
June 29, 2023
Filing Date:
December 23, 2022
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K31/4418; A61P9/00; A61P9/04; A61P43/00
Domestic Patent References:
| WO2019203176A1 | 2019-10-24 |
Other References:
IDE YUYA, HORIE TAKAHIRO, SAITO NARITATSU, WATANABE SHIN, OTANI CHIHARU, MIYASAKA YUI, KUWABARA YASUHIDE, NISHINO TOMOHIRO, NAKAO : "Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction", JACC: BASIC TO TRANSLATIONAL SCIENCE, vol. 4, no. 6, 1 October 2019 (2019-10-01), pages 701 - 714, XP055866427, ISSN: 2452-302X, DOI: 10.1016/j.jacbts.2019.06.001
PAULO LIZANO, RASHED EMAN, STOLL SHAUNRICK, ZHOU NING, WEN HAIRUO, HAYS TRISTAN T., QIN GANGJIAN, XIE LAI-HUA, DEPRE CHRISTOPHE, Q: "The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo", SCIENTIFIC REPORTS, vol. 7, no. 46324, 1 April 2017 (2017-04-01), XP055643321, DOI: 10.1038/srep46324
MATSUSHIMA, SHOJI: "HFpEF", SHINZO - HEART, NIHON SHINZO ZAIDAN, TOKYO, JP, vol. 53, no. 6, 15 June 2021 (2021-06-15), JP , pages 552 - 557, XP009547283, ISSN: 0586-4488, DOI: 10.11281/shinzo.53.552
PAULO LIZANO, RASHED EMAN, STOLL SHAUNRICK, ZHOU NING, WEN HAIRUO, HAYS TRISTAN T., QIN GANGJIAN, XIE LAI-HUA, DEPRE CHRISTOPHE, Q: "The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo", SCIENTIFIC REPORTS, vol. 7, no. 46324, 1 April 2017 (2017-04-01), XP055643321, DOI: 10.1038/srep46324
MATSUSHIMA, SHOJI: "HFpEF", SHINZO - HEART, NIHON SHINZO ZAIDAN, TOKYO, JP, vol. 53, no. 6, 15 June 2021 (2021-06-15), JP , pages 552 - 557, XP009547283, ISSN: 0586-4488, DOI: 10.11281/shinzo.53.552
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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