Title:
COMPOSITION FOR INCREASING NATURAL KILLER CELL ACTIVITY AND PREVENTING AND TREATING INFECTIOUS DISEASES AND CANCER USING PEPTIDE DERIVED FROM SARS-COV-2 S PROTEIN THAT BINDS TO NKG2D RECEPTOR ON NATURAL KILLER CELLS
Document Type and Number:
WIPO Patent Application WO/2022/114798
Kind Code:
A1
Abstract:
The present invention relates to a novel method for preparing natural killer cells with improved natural killer cell activity, and a use for same. The natural killer cells prepared according to the present invention have improved activity in terms of killing ability and IFN-γ production ability, etc. of the natural killer cells, and can thus be utilized for various uses as therapeutic agents for viral infections, immunotherapeutic agents, cancer therapeutic agents, and the like.
Inventors:
CHOI IN PYO (KR)
KIM HAN NA (KR)
JUNG HAI YOUNG (KR)
BYUN JAE EUN (KR)
YOON SUK RAN (KR)
KIM HAN NA (KR)
JUNG HAI YOUNG (KR)
BYUN JAE EUN (KR)
YOON SUK RAN (KR)
Application Number:
PCT/KR2021/017449
Publication Date:
June 02, 2022
Filing Date:
November 25, 2021
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C07K7/06; A61K35/17; A61P31/14; A61P31/16; A61P31/20; A61P35/00; C07K14/005; C12N5/0783
Foreign References:
| CN111454372A | 2020-07-28 |
Other References:
MUHAMMAD TAHIR UL QAMAR;FARAH SHAHID;SADIA ASLAM;USMANALI ASHFAQ;SIDRA ASLAM;ISRAR FATIMA;MUHAMMADMAZHAR FAREED;ALI ZOHAIB;LING-LI: "Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2", INFECTIOUS DISEASES OF POVERTY, vol. 9, no. 1, 16 September 2020 (2020-09-16), London, UK , pages 1 - 14, XP021281812, DOI: 10.1186/s40249-020-00752-w
BORTOLOTTI DARIA, GENTILI VALENTINA, RIZZO SABRINA, ROTOLA ANTONELLA, RIZZO ROBERTA: "SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway", CELLS, vol. 9, no. 9, 1 January 2020 (2020-01-01), pages 1 - 15, XP055934276, DOI: 10.3390/cells9091975
JEWETT ANAHID, JEWETT ANAHID: "The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions", FRONTIERS IN IMMUNOLOGY, vol. 11, 10 July 2020 (2020-07-10), pages 1 - 6, XP055934277, DOI: 10.3389/fimmu.2020.01692
VAN EEDEN CHARMAINE, KHAN LAMIA, OSMAN MOHAMMED S., COHEN TERVAERT JAN WILLEM: "Natural Killer Cell Dysfunction and Its Role in COVID-19", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 17, 1 January 2020 (2020-01-01), pages 1 - 18, XP055921473, DOI: 10.3390/ijms21176351
KIM HANNA, BYUN JAE-EUN, YOON SUK RAN, KOOHY HASHEM, JUNG HAIYOUNG, CHOI INPYO: "SARS-CoV-2 peptides bind to NKG2D and increase NK cell activity", CELLULAR IMMUNOLOGY, vol. 371, 1 January 2022 (2022-01-01), US , pages 1 - 8, XP055934283, ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2021.104454
MANN CHRISTIAN; GRIFFIN JUSTIN H.; DOWNARD KEVIN M.: "Detection and evolution of SARS-CoV-2 coronavirus variants of concern with mass spectrometry", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 413, no. 29, 16 September 2021 (2021-09-16), Berlin/Heidelberg, pages 7241 - 7249, XP037617783, ISSN: 1618-2642, DOI: 10.1007/s00216-021-03649-1
BORTOLOTTI DARIA, GENTILI VALENTINA, RIZZO SABRINA, ROTOLA ANTONELLA, RIZZO ROBERTA: "SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway", CELLS, vol. 9, no. 9, 1 January 2020 (2020-01-01), pages 1 - 15, XP055934276, DOI: 10.3390/cells9091975
JEWETT ANAHID, JEWETT ANAHID: "The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions", FRONTIERS IN IMMUNOLOGY, vol. 11, 10 July 2020 (2020-07-10), pages 1 - 6, XP055934277, DOI: 10.3389/fimmu.2020.01692
VAN EEDEN CHARMAINE, KHAN LAMIA, OSMAN MOHAMMED S., COHEN TERVAERT JAN WILLEM: "Natural Killer Cell Dysfunction and Its Role in COVID-19", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 17, 1 January 2020 (2020-01-01), pages 1 - 18, XP055921473, DOI: 10.3390/ijms21176351
KIM HANNA, BYUN JAE-EUN, YOON SUK RAN, KOOHY HASHEM, JUNG HAIYOUNG, CHOI INPYO: "SARS-CoV-2 peptides bind to NKG2D and increase NK cell activity", CELLULAR IMMUNOLOGY, vol. 371, 1 January 2022 (2022-01-01), US , pages 1 - 8, XP055934283, ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2021.104454
MANN CHRISTIAN; GRIFFIN JUSTIN H.; DOWNARD KEVIN M.: "Detection and evolution of SARS-CoV-2 coronavirus variants of concern with mass spectrometry", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 413, no. 29, 16 September 2021 (2021-09-16), Berlin/Heidelberg, pages 7241 - 7249, XP037617783, ISSN: 1618-2642, DOI: 10.1007/s00216-021-03649-1
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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