Title:
COMPOSITION FOR INDUCING DIRECT REPROGRAMMING COMPRISING SELF-ASSEMBLED RNA CONSTRUCT
Document Type and Number:
WIPO Patent Application WO/2023/068826
Kind Code:
A1
Abstract:
The present invention relates to a composition for direct reprogramming comprising a three-dimensional RNA construct formed by the self-assembly of transcript repeatedly comprising, as a unit sequence, mRNA for transcription factor expression or RNA for RNA interference for transcription factor expression suppression. The composition for direct reprogramming can cause a stable and efficient direct reprogramming.
Inventors:
LEE JONG BUM (KR)
KIM HYEJIN (KR)
KIM HYEJIN (KR)
Application Number:
PCT/KR2022/015999
Publication Date:
April 27, 2023
Filing Date:
October 20, 2022
Export Citation:
Assignee:
UNIV SEOUL IND COOP FOUND (KR)
International Classes:
C12N15/113; C12N5/077; C12N15/90
Foreign References:
| KR20200142537A | 2020-12-22 | |||
| KR20200046966A | 2020-05-07 |
Other References:
UNIVERSITY OF SEOUL: "Development of a novel method for reprogramming through the delivery of RNA nanostructure without chromosomal integration. RNA 나노구조체 전달을 통한 신개념 염색체 비삽입형 세포전환 기술 개발", 2021년도 바이오⋅의료기술개발사업 최종보고서 (FINAL REPORT OF 2021 BIO⋅MEDICAL TECHNOLOGY DEVELOPMENT PROJECT), 31 March 2021 (2021-03-31), pages 1 - 73, XP093058385, Retrieved from the Internet > [retrieved on 20230627]
FU ZHENG; ZHANG XIANG; ZHOU XINYAN; UR-REHMAN UZAIR; YU MENGCHAO; LIANG HONGWEI; GUO HONGYUAN; GUO XU; KONG YAN; SU YUANYUAN; YE Y: "In vivo self-assembled small RNAs as a new generation of RNAi therapeutics", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 31, no. 6, 29 March 2021 (2021-03-29), Singapore , pages 631 - 648, XP037469825, ISSN: 1001-0602, DOI: 10.1038/s41422-021-00491-z
CULHA UTKU, DAVIDSON ZOEY S., MASTRANGELI MASSIMO, SITTI METIN: "Statistical reprogramming of macroscopic self-assembly with dynamic boundaries", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 21, 26 May 2020 (2020-05-26), pages 11306 - 11313, XP093058393, ISSN: 0027-8424, DOI: 10.1073/pnas.2001272117
FU ZHENG; ZHANG XIANG; ZHOU XINYAN; UR-REHMAN UZAIR; YU MENGCHAO; LIANG HONGWEI; GUO HONGYUAN; GUO XU; KONG YAN; SU YUANYUAN; YE Y: "In vivo self-assembled small RNAs as a new generation of RNAi therapeutics", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 31, no. 6, 29 March 2021 (2021-03-29), Singapore , pages 631 - 648, XP037469825, ISSN: 1001-0602, DOI: 10.1038/s41422-021-00491-z
CULHA UTKU, DAVIDSON ZOEY S., MASTRANGELI MASSIMO, SITTI METIN: "Statistical reprogramming of macroscopic self-assembly with dynamic boundaries", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 21, 26 May 2020 (2020-05-26), pages 11306 - 11313, XP093058393, ISSN: 0027-8424, DOI: 10.1073/pnas.2001272117
Attorney, Agent or Firm:
IPCJ PATENT & LAW FIRM (KR)
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