Title:
COMPOSITION FOR INDUCING TRANSDIFFERENTIATION AND STEM CELLS TREATED THEREWITH
Document Type and Number:
WIPO Patent Application WO/2023/090971
Kind Code:
A1
Abstract:
The present invention relates to a composition for inducing transdifferentiation through oligomerization of CtBPs, and uses of stem cells treated therewith. Since the compounds of the present invention can induce transdifferentiation of adult stem cells into neural progenitor cells by regulating the oligomerization of CtBPs, the compounds can be used for inducing oligomerization or transdifferentiation of CtBPs. In addition, since ciNSC5 derived from transdifferentiation exhibits remarkable therapeutic effects in an ALS mouse model, an MS mouse model, a PD rat model, and a chronic spinal cord injury rat model, ciNSC5 can be used as a cellular therapeutic agent.
Inventors:
YUNE TAE YOUNG (KR)
LEE JEE YOUN (KR)
LEE JEE YOUN (KR)
Application Number:
PCT/KR2022/018430
Publication Date:
May 25, 2023
Filing Date:
November 21, 2022
Export Citation:
Assignee:
YJ CERAPEUTICS INC (KR)
International Classes:
C12N5/0775; A61K35/28; A61P25/00
Domestic Patent References:
| WO2021100889A1 | 2021-05-27 |
Foreign References:
| KR20190041897A | 2019-04-23 | |||
| KR20190135112A | 2019-12-06 |
Other References:
SUBIR K. RAY; HUI J. LI; ANDREW B. LEITER: "Oligomeric form of C‐terminal‐binding protein coactivates NeuroD1‐mediated transcription", FEBS LETTERS, ELSEVIER, AMSTERDAM., NL, vol. 591, no. 1, 19 December 2016 (2016-12-19), NL , pages 205 - 212, XP071255429, ISSN: 0014-5793, DOI: 10.1002/1873-3468.12501
STANKIEWICZ TRISHA R., GRAY JOSIE J., WINTER AIMEE N., LINSEMAN DANIEL A.: "C-terminal binding proteins: central players in development and disease", BIOMOLECULAR CONCEPTS, WALTER DE GRUYTER GMBH, DE, vol. 5, no. 6, 1 December 2014 (2014-12-01), DE , pages 489 - 511, XP093068174, ISSN: 1868-5021, DOI: 10.1515/bmc-2014-0027
STANKIEWICZ TRISHA R., GRAY JOSIE J., WINTER AIMEE N., LINSEMAN DANIEL A.: "C-terminal binding proteins: central players in development and disease", BIOMOLECULAR CONCEPTS, WALTER DE GRUYTER GMBH, DE, vol. 5, no. 6, 1 December 2014 (2014-12-01), DE , pages 489 - 511, XP093068174, ISSN: 1868-5021, DOI: 10.1515/bmc-2014-0027
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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