Title:
COMPOSITION FOR INHIBITING TUMOR GROWTH, CONTAINING EXTRACT OF SANGUISORBA OFFICINALIS AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/235050
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting tumor growth, containing an extract of Sanguisorba officinalis as an active ingredient. It has been identified that a Sanguisorba officinalis extract binds to PD-L1 on cancer cell surfaces to block the interaction of cancer cells with PD-1 on the surface of T cells, and thus activates T cells to exhibit the effect of inhibiting tumor growth, and the present invention can reduce the size and weight of a tumor by being administered to an animal model in which colon cancer has been induced, and can increase immune cells (CD8 T cells) and granzyme B secretion in cancer tissues.
More Like This:
Inventors:
CHUNG HWAN SUCK (KR)
LEE EUN-JI (KR)
CHOI JANG GI (KR)
KIM JI HYE (KR)
KIM YOUNG SOO (KR)
KIM TAEIN (KR)
LI WEI (KR)
LEE EUN-JI (KR)
CHOI JANG GI (KR)
KIM JI HYE (KR)
KIM YOUNG SOO (KR)
KIM TAEIN (KR)
LI WEI (KR)
Application Number:
PCT/KR2022/006326
Publication Date:
November 10, 2022
Filing Date:
May 03, 2022
Export Citation:
Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
International Classes:
A23L33/105; A61K31/538; A61K36/739; A61K45/06; A61P31/00; A61P35/00; A61P43/00
Foreign References:
| KR20170055104A | 2017-05-19 |
Other References:
CAI ZIBIN, LI WEI, WANG HAOTIAN, YAN WEIQUN, ZHOU YULAI, WANG GUANJUN, CUI JIUWEI, WANG FANG: "Anti-tumor and immunomodulating activities of a polysaccharide from the root of Sanguisorba officinalis L.", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ELSEVIER BV, NL, vol. 51, no. 4, 1 November 2012 (2012-11-01), NL , pages 484 - 488, XP093000697, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2012.05.029
LIU MENG-PING, LIAO MIN, DAI CONG, CHEN JIE-FENG, YANG CHUN-JUAN, LIU MING, CHEN ZUAN-GUANG, YAO MEI-CUN: "Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway", SCIENTIFIC REPORTS, vol. 6, no. 1, 30 September 2016 (2016-09-30), XP093000694, DOI: 10.1038/srep34245
WANG NENG, MUHETAER GULIZEBA, ZHANG XIAOTONG, YANG BOWEN, WANG CAIWEI, ZHANG YU, WANG XUAN, ZHANG JUPING, WANG SHENGQI, ZHENG YIFE: "Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling", FRONTIERS IN PHARMACOLOGY, vol. 11, XP093000692, DOI: 10.3389/fphar.2020.591400
LIU MENG-PING, LI WA, DAI CONG, KEI LAM CHRISTOPHER WAI, LI ZHENG, CHEN JIE-FENG, CHEN ZUAN-GUANG, ZHANG WEI, YAO MEI-CUN: "Aqueous extract of Sanguisorba officinalis blocks the Wnt/β-catenin signaling pathway in colorectal cancer cells", RSC ADVANCES, vol. 8, no. 19, 1 January 2018 (2018-01-01), pages 10197 - 10206, XP093000690, DOI: 10.1039/C8RA00438B
LEE EUN-JI, KIM JI HYE, KIM TAE IN, KIM YEON-JI, PAK MALK EUN, JEON CHANG HYUN, PARK YEO JIN, LI WEI, KIM YOUNG SOO, CHOI JANG-GI,: "Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model", FRONTIERS IN IMMUNOLOGY, vol. 12, 29 September 2021 (2021-09-29), XP093000689, DOI: 10.3389/fimmu.2021.737076
LIU MENG-PING, LIAO MIN, DAI CONG, CHEN JIE-FENG, YANG CHUN-JUAN, LIU MING, CHEN ZUAN-GUANG, YAO MEI-CUN: "Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway", SCIENTIFIC REPORTS, vol. 6, no. 1, 30 September 2016 (2016-09-30), XP093000694, DOI: 10.1038/srep34245
WANG NENG, MUHETAER GULIZEBA, ZHANG XIAOTONG, YANG BOWEN, WANG CAIWEI, ZHANG YU, WANG XUAN, ZHANG JUPING, WANG SHENGQI, ZHENG YIFE: "Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling", FRONTIERS IN PHARMACOLOGY, vol. 11, XP093000692, DOI: 10.3389/fphar.2020.591400
LIU MENG-PING, LI WA, DAI CONG, KEI LAM CHRISTOPHER WAI, LI ZHENG, CHEN JIE-FENG, CHEN ZUAN-GUANG, ZHANG WEI, YAO MEI-CUN: "Aqueous extract of Sanguisorba officinalis blocks the Wnt/β-catenin signaling pathway in colorectal cancer cells", RSC ADVANCES, vol. 8, no. 19, 1 January 2018 (2018-01-01), pages 10197 - 10206, XP093000690, DOI: 10.1039/C8RA00438B
LEE EUN-JI, KIM JI HYE, KIM TAE IN, KIM YEON-JI, PAK MALK EUN, JEON CHANG HYUN, PARK YEO JIN, LI WEI, KIM YOUNG SOO, CHOI JANG-GI,: "Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model", FRONTIERS IN IMMUNOLOGY, vol. 12, 29 September 2021 (2021-09-29), XP093000689, DOI: 10.3389/fimmu.2021.737076
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
Download PDF: