Title:
COMPOSITION AND KIT FOR DIFFERENTIATION OF STEM CELLS INTO NEURAL CREST STEM CELLS, INCLUDING INHIBITOR OF TGF-BETA I RECEPTOR AND BMP INHIBITOR, AND METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2020/145708
Kind Code:
A1
Abstract:
Provided are a composition and a kit for differentiation of stem cells into neural crest stem cells (NCSCs), comprising an inhibitor of the transforming growth factor beta (TGF-β) I receptor and 0.001 μM to 2.5 μM of a bone morphogenetic protein (BMP) inhibitor, and a method using same. According to the present invention, it is possible to efficiently differentiate stem cells to neural crest stem cells using an inexpensive composition of simple ingredients.
Inventors:
HWANG DONG YOUN (KR)
Application Number:
PCT/KR2020/000437
Publication Date:
July 16, 2020
Filing Date:
January 10, 2020
Export Citation:
Assignee:
UNIV CHA IND ACAD COOP FOUND (KR)
International Classes:
C12N5/079
Foreign References:
| US20160237405A1 | 2016-08-18 | |||
| US20170260501A1 | 2017-09-14 | |||
| KR20180105236A | 2018-09-27 | |||
| US20150299652A1 | 2015-10-22 | |||
| KR20150059861A | 2015-06-03 |
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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