Title:
COMPOSITION AND METHOD FOR 3D PRINTING OF LIVING CELLS
Document Type and Number:
WIPO Patent Application WO/2023/060747
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of biomaterials, and specifically relates to a composition for 3D printing of living cells and a method for 3D printing of living cells. The composition comprises a double bond-modified positively charged amino material, a double bond-modified sodium alginate and an ultraviolet light initiator. The composition can print a basic structure which contains cells and has a good fidelity under room temperature conditions, can be cured by means of ultraviolet cross-linking in a short period of time, and can be applied to the printing of living cells. The method not only solves the instability of traditional calcium ion cross-linked sodium alginate scaffolds and greatly improves the efficiency of 3D printing, but also improves the bioinertia of sodium alginate; and the obtained polyelectrolyte-based double bond cross-linked network hydrogel scaffold has good biocompatibility to cells, which further expands the application value of sodium alginate in the field of tissue engineering.
Inventors:
RUAN CHANGSHUN (CN)
TANG LAN (CN)
CHEN ZHIGANG (CN)
GAO CHONGJIAN (CN)
YANG JIRONG (CN)
TANG LAN (CN)
CHEN ZHIGANG (CN)
GAO CHONGJIAN (CN)
YANG JIRONG (CN)
Application Number:
PCT/CN2021/138115
Publication Date:
April 20, 2023
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61L27/38; A61L27/16; A61L27/18; A61L27/20; A61L27/52; B33Y70/10
Foreign References:
| CN112646100A | 2021-04-13 | |||
| CN111334461A | 2020-06-26 | |||
| CN113101420A | 2021-07-13 | |||
| CN109464700A | 2019-03-15 | |||
| CN108187145A | 2018-06-22 | |||
| US20200262802A1 | 2020-08-20 |
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF: