Title:
COMPOSITION AND METHOD FOR INDUCING BONE GROWTH AND HEALING
Document Type and Number:
WIPO Patent Application WO2003070186
Kind Code:
A3
Abstract:
A composition and method for inducing bone growth and healing is provided. The composition comprises a bone endogenous material, and has both a flow and a congealed phase. The composition is applied in the flow phase within the demand medullary canal (18) of a long bone (20), then an endoprosthesis (30) is inserted. The composition undergoes a phase change to the congealed phase, for example, via cross-linking of the bone endogenous material, providing a compliant barrier layer (10). The resultant barrier layer (10) has a first order porosity to accommodate convective diffusion of nutrient species and a second order porosity to accommodate osteoblastic migration therein without the need for osteoclastic resorption. In a preferred embodiment, the second order porosity is provided via a rapidly degrading polymer added to the composition having a half-life for degradation of 1-60 days.
Inventors:
KNOTHE TATE MELISSA L (US)
KNOTHE ULF R (US)
KNOTHE ULF R (US)
Application Number:
PCT/US2003/004858
Publication Date:
February 24, 2005
Filing Date:
February 20, 2003
Export Citation:
Assignee:
CLEVELAND CLINIC FOUNDATION (US)
KNOTHE TATE MELISSA L (US)
KNOTHE ULF R (US)
KNOTHE TATE MELISSA L (US)
KNOTHE ULF R (US)
International Classes:
A61L27/18; A61L27/36; A61L27/38; A61L27/48; A61L27/56; A61L27/58; (IPC1-7): A61F2/36
Foreign References:
| US6077916A | 2000-06-20 |
Download PDF:
Previous Patent: METHOD FOR TREATING CELLULITE
Next Patent: FUSION PROTEINS OF MYCOBACTERIUM TUBERCULOSIS
Next Patent: FUSION PROTEINS OF MYCOBACTERIUM TUBERCULOSIS