COMPOSITION AND METHOD FOR INHIBITING PLATELET AGGREGATION

WIPO Patent Application WO2002016381

B1

This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Y12 receptor antagonist compound, wherein said amount is effective to bind the P2Y12 receptors on platelets and inhibit ADP-induced platelet aggregation. The P2Y12 receptor antagonist compounds useful for this invention include mononucleoside polyphosphates and dinucleoside polyphosphates of general Formula (I), or salts thereof. The present invention also provides novel compositions comprising mononucleoside polyphosphates and dinucleoside polyphosphates according to Formula (Ia) and (Ib).

BOYER JOSE L (US)
OLINS GILLIAN M (US)
YERXA BENJAMIN R (US)
DOUGLASS JAMES G (US)

PCT/US2001/041818

August 15, 2002

August 20, 2001

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INSPIRE PHARMACEUTICALS INC (US)
UNIV NORTH CAROLINA (US)
BOYER JOSE L (US)
OLINS GILLIAN M (US)
YERXA BENJAMIN R (US)
DOUGLASS JAMES G (US)

A61K31/7072; A61K31/708; A61K31/7084; A61K38/43; A61K45/00; A61P7/00; A61P7/02; A61P7/08; A61P7/12; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P13/00; A61P13/12; A61P15/00; A61P15/06; A61P17/02; A61P19/04; A61P25/06; A61P29/00; A61P31/04; A61P37/00; A61P39/00; A61P41/00; A61P43/00; C07F9/6561; C07H19/04; C07H19/10; C07H19/20; C07H19/207; C07H21/00; C07H21/02; C07H21/04; (IPC1-7): C07H19/10; A61K31/7072; A61K31/7076; A61P7/02; C07H19/20; C07H19/207

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