Title:
COMPOSITION AND METHOD FOR REDUCING FREE RADICAL CELLULAR OXIDATIVE STRESS IN WARM-BLOODED ANIMALS
Document Type and Number:
WIPO Patent Application WO/1993/010777
Kind Code:
A1
Abstract:
A method for reducing free radical cellular oxidative stress in warm-blooded animals showing symptoms of free radical toxicity is disclosed. The method comprises the steps of confirming the presence of a free radical cellular oxidative stress in the animal; determining which trace minerals selected from the group consisting of copper, zinc, iron and manganese, with or without optional amounts of selenium are needed to strengthen and maintain the functioning of enzymes which relate to oxidative bursts in neutrophils and macrophages in the animal; providing a composition containing effective amounts of at least one of the minerals copper, zinc, iron and manganese in the form of an amino acid chelate having a ligand to mineral ratio of at least 1:1, a molecular weight of no more than 1500 daltons and a stability constant of between about 106 and 1016, with or without optional amounts of selenium which may be present either in amino acid chelated form or as inorganic selenium, and administering the composition to the animal, preferably in oral form. The presence of free radical cellular oxidative stress is preferably confirmed by direct assay of the activity of oxidative enzymes selected from the group consisting of CuZnSOD, glutathione peroxidase and catalase.
Inventors:
ASHMEAD H DEWAYNE (US)
ASHMEAD HARVEY H (US)
JEPPSON ROBERT B (US)
ASHMEAD HARVEY H (US)
JEPPSON ROBERT B (US)
Application Number:
PCT/US1992/009587
Publication Date:
June 10, 1993
Filing Date:
November 05, 1992
Export Citation:
Assignee:
ALBION INT (US)
International Classes:
A61K31/28; A61K31/295; A61K31/30; A61K31/315; A61K33/04; (IPC1-7): A61K31/28; A61K31/295; A61K31/30; A61K31/315
Foreign References:
| US4863898A | 1989-09-05 |
Other References:
FASEBJ.1:441-445; 1987, MACHLIN, L.J. et al., "Free Radical Tissue Damage: Protective Role of Antioxidant Nutrients", see page 443, column 2 and Table 2 and page 444, columns 1-2.
See also references of EP 0614361A4
See also references of EP 0614361A4
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