Title:
COMPOSITION FOR ORAL ADMINISTRATION
Document Type and Number:
WIPO Patent Application WO/2007/043538
Kind Code:
A1
Abstract:
Disclosed are: a composition for oral administration which enables the production of an molded product for oral administration (e.g., a preparation having both rapid disintegrating property and high hardness) at low cost by using a general-purpose apparatus; a molded product for oral administration which is an application example of the composition; and a method for production of the composition. The composition can be produced by a process comprising the steps of: treating a granulation composition comprising a δ-type D-mannitol crystal and a disintegrating agent (e.g., crospovidone) with a water-soluble solvent to convert at least a part of the δ-type D-mannitol crystal into a β-type D-mannitol crystal; and drying the granulation composition to inhibit the growth of the β-type D-mannitol crystal produced by the conversion.
Inventors:
MAKINO TADASHI (JP)
FUKAMI JINICHI (JP)
FUKAMI JINICHI (JP)
Application Number:
PCT/JP2006/320235
Publication Date:
April 19, 2007
Filing Date:
October 04, 2006
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
MAKINO TADASHI (JP)
FUKAMI JINICHI (JP)
MAKINO TADASHI (JP)
FUKAMI JINICHI (JP)
International Classes:
A61K47/10; A61K9/14; A61K9/20; A61K45/00; A61K47/32; A61K47/38; A61K31/133; A61K31/196; A61K31/40; A61K31/4155; A61K31/427; A61K31/435; A61K31/44; A61K31/4409; A61K31/4427; A61K31/4439; A61K31/445; A61K31/495; A61K31/541; A61K31/5517
Domestic Patent References:
| WO2006106923A1 | 2006-10-12 | |||
| WO2002069933A1 | 2002-09-12 | |||
| WO2003074085A1 | 2003-09-12 |
Foreign References:
| JPH1036291A | 1998-02-10 |
Other References:
YOSHINARI T. ET AL.: "THE IMPROVED COMPACTION PROPERTIES OF MANNITOL AFTER A MOISTURE-INDUCED POLYMORPHIC TRANSITION", INT. J. PHARM., vol. 258, no. 1-2, 2003, pages 121 - 131, XP003002442
MAKINO T.: "Seizai Gijutsu no Iki o Atsumeta Kokunai Hokai Seizai eno Kitai (Expectations to Orally Disintegratin Dosage Forms collecting essences of Pharmaceutical Technology", PHARM. TECH. JPN., vol. 22, no. 4, 1 April 2006 (2006-04-01), pages 597 - 601, XP003010429
MAKINO T.: "Seizai Gijutsu no Iki o Atsumeta Kokunai Hokai Seizai eno Kitai (Expectations to Orally Disintegratin Dosage Forms collecting essences of Pharmaceutical Technology", PHARM. TECH. JPN., vol. 22, no. 4, 1 April 2006 (2006-04-01), pages 597 - 601, XP003010429
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, JP)
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