Title:
COMPOSITION FOR PREVENTING, IMPROVING OR TREATING DEGENERATIVE NEUROLOGICAL DISEASE COMPRISING FRACTION OF A
QUILARIA AGALLOCHA
ROXBURGH EXTRACT AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/151547
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, improving or treating degenerative neurological diseases comprising a fraction of Aquilaria agallocha Roxburgh extract as an active ingredient. The composition comprising a fraction of Aquilaria agallocha Roxburgh extract as an active ingredient according to the present invention exhibits antioxidant activity, inhibition of apoptosis of neuronal cells, inhibition of cranial nerve stress, neuronal cell protection, inhibition of the production of reactive oxygen species (ROS) in neuronal cells, decrease in phosphorylation level of extracellular signal-regulated kinases (ERK), inhibition of the production of nitric oxide (NO) in neuronal cells, and inhibition of DNA segmentation of neuronal cells. Accordingly, the composition has an effect on degenerative neurological diseases, such as Alzheimer's disease, Parkinson's disease, Lou Gehrig disease, Huntington's disease, multiple sclerosis, stroke, thrombosis, embolism, head trauma, metabolic disorder of cerebral circulation, brain functional coma or dementia, etc.
Inventors:
SON CHANG GUE (KR)
LEE SAM KEUN (KR)
LEE JIN SEOK (KR)
LEE SAM KEUN (KR)
LEE JIN SEOK (KR)
Application Number:
PCT/KR2018/001339
Publication Date:
August 08, 2019
Filing Date:
January 31, 2018
Export Citation:
Assignee:
DAEJEON UNIV INDUSTRY UNIV COOPERATION FOUNDATION (KR)
International Classes:
A61K36/835; A23L33/105; A61P25/00; A61P25/16; A61P25/28
Foreign References:
| JP2017537146A | 2017-12-14 | |||
| KR20130102273A | 2013-09-17 | |||
| KR20090112268A | 2009-10-28 |
Other References:
SUPASUTEEKUL, C. ET AL.: "Neuritogenic and neuroprotective constituents form Aquilarial crassna leaves", JOURNAL OF FOOD BIOCHEMISTRY, vol. 41, no. 3, 6 March 2017 (2017-03-06), pages 1 (e12365) - 8, XP055629233
YANG, D. L. ET AL.: "Fragrant agarofuran and eremophilane sesquiterpenes in agarwood 'Qi-Nan' from Aquilaria sinesis", PHYTOCHEMISTRY LETTERS, vol. 8, 22 March 2014 (2014-03-22) - May 2014 (2014-05-01), pages 121 - 135, XP055629241
LEE, H. -Y. ET AL.: "The ethanol extract of Aquilariae Lignum ameliorates hippocampal oxidative stress in a repeated restraint stress mouse model", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 17, no. 397, 2017, pages 1 - 12, XP021247762
LEE, H. -Y. ET AL.: "Ethanol extract of Aquilariae Lignum ameliorates hippocampal oxidative stress in a repeated restraint stress mouse model", 9TH DAEJEON UNIVERSITY POSTER-DAY, 5 December 2017 (2017-12-05), pages 1
YANG, D. L. ET AL.: "Fragrant agarofuran and eremophilane sesquiterpenes in agarwood 'Qi-Nan' from Aquilaria sinesis", PHYTOCHEMISTRY LETTERS, vol. 8, 22 March 2014 (2014-03-22) - May 2014 (2014-05-01), pages 121 - 135, XP055629241
LEE, H. -Y. ET AL.: "The ethanol extract of Aquilariae Lignum ameliorates hippocampal oxidative stress in a repeated restraint stress mouse model", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 17, no. 397, 2017, pages 1 - 12, XP021247762
LEE, H. -Y. ET AL.: "Ethanol extract of Aquilariae Lignum ameliorates hippocampal oxidative stress in a repeated restraint stress mouse model", 9TH DAEJEON UNIVERSITY POSTER-DAY, 5 December 2017 (2017-12-05), pages 1
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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