Title:
COMPOSITION FOR PREVENTING, IMPROVING, OR TREATING MUSCULAR ATROPHY, CONTAINING GOMISIN G AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/096214
Kind Code:
A1
Abstract:
A composition containing gomisin G as an active ingredient, according to the present invention, has been confirmed to inhibit protein expression of myostatin, atrogin1, MuRF1 which are involved in muscle degradation, and it has been confirmed that, when a small amount of gomisin G is administered in a hindlimb immobilization-induced muscular atrophy mouse model, a muscle strength improvement effect is achieved by enabling changing from fast muscle fibers to slow muscle fibers through increased mitochondrial biogenesis, and the composition has been confirmed to have the effect of preventing, improving, or treating muscular atrophy by increasing muscle mass or inhibiting decreased muscle mass by regulating a gene involved in muscle protein synthesis and muscle protein decay, and thus the composition for preventing, improving, or treating muscular atrophy, containing gomisin G as an active ingredient of the present invention may be usefully employed as a health functional food and a pharmaceutical composition.
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Inventors:
JUN HEE-SOOK (KR)
YEON MYEONGHOON (KR)
YEON MYEONGHOON (KR)
Application Number:
PCT/KR2023/006936
Publication Date:
May 10, 2024
Filing Date:
May 22, 2023
Export Citation:
Assignee:
UNIV GACHON IND ACAD COOP FOUND (KR)
International Classes:
A61K31/36; A23L33/10; A61K36/79; A61P21/00
Foreign References:
| KR20190044171A | 2019-04-30 | |||
| KR20210126376A | 2021-10-20 |
Other References:
YEON MYEONGHOON; CHOI HOJUNG; CHUN KWANG-HOON; LEE JONG HAN; JUN HEE-SOOK: "Gomisin G improves muscle strength by enhancing mitochondrial biogenesis and function in disuse muscle atrophic mice", BIOMEDICINE & PHARMACOTHERAPY, vol. 153, 14 July 2022 (2022-07-14), FR , XP087168197, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2022.113406
YEON, M. H. et al. Gomisin G improves immobilization-induced skeletal muscle atrophy. 대한약학회 춘계국제학술대회 (Spring International Convention of the Pharmaceutical Society of Korea). 21-22 April 2022.
YEON, M. H. ET AL. PREVENTIVE EFFECTS OF SCHISANDRIN A: "a bioactive component of schisandra chinensis", ON DEXAMETHASONE-INDUCED MUSCLE ATROPHY. NUTRIENTS. 2020, vol. 1255, vol. 12, pages 1 - 13
YEON, M. H. et al. Gomisin G improves immobilization-induced skeletal muscle atrophy. 대한약학회 춘계국제학술대회 (Spring International Convention of the Pharmaceutical Society of Korea). 21-22 April 2022.
YEON, M. H. ET AL. PREVENTIVE EFFECTS OF SCHISANDRIN A: "a bioactive component of schisandra chinensis", ON DEXAMETHASONE-INDUCED MUSCLE ATROPHY. NUTRIENTS. 2020, vol. 1255, vol. 12, pages 1 - 13
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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