Title:
COMPOSITION FOR PREVENTING OR TREATING BACTERIAL INFECTIOUS DISEASE COMPRISING 4-GINGEROL DERIVATIVE COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/040333
Kind Code:
A1
Abstract:
The present invention relates to a 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof, the compound being capable of inhibiting biofilm formation and production of virulence factors. The 4-gingerol derivative compound according to the present invention has binding affinity to RhlR and corresponding RhlR antagonism activity that are significantly improved, and therefore can effectively inhibit biofilm formation and production of virulence factors. Furthermore, various bacterial infectious diseases caused by biofilms can be fundamentally prevented or treated by using a pharmaceutical composition comprising the 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof as an active ingredient.
Inventors:
BYUN YOUNGJOO (KR)
PARK HEE DEUNG (KR)
NAM SANGJIN (KR)
SON SANG-HYUN (KR)
HAM SO YOUNG (KR)
KIM HAN SHIN (KR)
PARK HEE DEUNG (KR)
NAM SANGJIN (KR)
SON SANG-HYUN (KR)
HAM SO YOUNG (KR)
KIM HAN SHIN (KR)
Application Number:
PCT/KR2020/011180
Publication Date:
March 04, 2021
Filing Date:
August 21, 2020
Export Citation:
Assignee:
UNIV KOREA RES & BUSINESS FOUNDATION SEJONG CAMPUS (KR)
UNIV KOREA RES & BUS FOUND (KR)
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07C49/235; A61K31/045; A61K31/085; A61K31/12; A61P31/04; C07C49/163; C07C49/172; C07C49/213
Foreign References:
| KR20190010436A | 2019-01-30 | |||
| CN103159599A | 2013-06-19 |
Other References:
GAIRE BHAKTA PRASAD, KWON OH WOOK, PARK SUNG HYUK, CHUN KWANG-HOON, KIM SUN YEOU, SHIN DONG YUN, CHOI JI WOONG: "Neuroprotective Effect of 6-Paradol in Focal Cerebral Ischemia Involves the Attenuation of Neuroinflammatory Responses in Activated Microglia", PLOS ONE, vol. 10, no. 3, pages e0120203, XP055786824, DOI: 10.1371/journal.pone.0120203
KIM HAN-SHIN, LEE SANG-HOON, BYUN YOUNGJOO, PARK HEE-DEUNG: "6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition", SCIENTIFIC REPORTS, vol. 5, no. 1, 1 August 2015 (2015-08-01), XP055786828, DOI: 10.1038/srep08656
HYUNSUK CHOI, SO-YOUNG HAM, EUNJI CHA, YUJIN SHIN, HAN-SHIN KIM, JEONG KYU BANG, SANG-HYUN SON, HEE-DEUNG PARK, YOUNGJOO BYUN: "Structure–Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 60, no. 23, 14 December 2017 (2017-12-14), pages 9821 - 9837, XP055480682, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01426
NAM SANGJIN, HAM SO-YOUNG, KWON HONGMOK, KIM HAN-SHIN, MOON SUHYUN, LEE JEONG-HOON, LIM TAEHYEONG, SON SANG-HYUN, PARK HEE-DEUNG, : "Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 63, no. 15, 13 August 2020 (2020-08-13), pages 8388 - 8407, XP055786830, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00630
KIM HAN-SHIN, LEE SANG-HOON, BYUN YOUNGJOO, PARK HEE-DEUNG: "6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition", SCIENTIFIC REPORTS, vol. 5, no. 1, 1 August 2015 (2015-08-01), XP055786828, DOI: 10.1038/srep08656
HYUNSUK CHOI, SO-YOUNG HAM, EUNJI CHA, YUJIN SHIN, HAN-SHIN KIM, JEONG KYU BANG, SANG-HYUN SON, HEE-DEUNG PARK, YOUNGJOO BYUN: "Structure–Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 60, no. 23, 14 December 2017 (2017-12-14), pages 9821 - 9837, XP055480682, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01426
NAM SANGJIN, HAM SO-YOUNG, KWON HONGMOK, KIM HAN-SHIN, MOON SUHYUN, LEE JEONG-HOON, LIM TAEHYEONG, SON SANG-HYUN, PARK HEE-DEUNG, : "Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 63, no. 15, 13 August 2020 (2020-08-13), pages 8388 - 8407, XP055786830, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00630
Attorney, Agent or Firm:
DAHAI INTERNATIONAL PATENT & LAW FIRM (KR)
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