Title:
COMPOSITION FOR PREVENTING OR TREATING BONE DISEASES WHICH HAS EXCELLENT BONE REGENERATION EFFECT
Document Type and Number:
WIPO Patent Application WO/2018/151514
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating bone diseases, comprising a BMP-2-encoding gene and HSV-tk-encoding gene, and as an active ingredient a stem cell into which a dual kill switch expression vector in which an HGPRT-encoded gene is knocked out is introduced or a cell differentiated from the stem cell, wherein the bone regeneration effect is realized by a BMP-2 growth factor and at the same time, apoptosis may also be dually controlled by the dual kill switch.
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Inventors:
SONG JAE JUN (KR)
SONG HO SEOK (KR)
GO YOON YOUNG (KR)
SONG HO SEOK (KR)
GO YOON YOUNG (KR)
Application Number:
PCT/KR2018/001910
Publication Date:
August 23, 2018
Filing Date:
February 14, 2018
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K35/545; A61K35/28; A61K35/32; A61K35/33
Foreign References:
| KR20110132579A | 2011-12-08 | |||
| KR101032871B1 | 2011-05-06 | |||
| KR20110011471A | 2011-02-08 | |||
| US20150376650A1 | 2015-12-31 | |||
| KR20130109417A | 2013-10-08 |
Other References:
CHUNG, Y.-H. O ET AL.: "Requirement of de novo protein synthesis for aminopterin-induced apoptosis in a mouse myeloma cell line", IMMUNOLOGY LETTERS, vol. 77, 2001, pages 127 - 131, XP055536674
RAWADI, G.: "BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 18, no. 10, 2003, pages 1842 - 1853, XP008138541
RAWADI, G.: "BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 18, no. 10, 2003, pages 1842 - 1853, XP008138541
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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