Title:
COMPOSITION FOR PREVENTING OR TREATING BREAST CANCER INCLUDING SALIDROSIDE AND BETULIN AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2018/186523
Kind Code:
A1
Abstract:
The present invention relates to a composition which is for preventing or treating breast cancer and includes salidroside and betulin as active ingredients. The composition according to the present invention including a mixture in which salidroside and betulin are mixed in a mass ratio of 2:1 or 1:2 exhibits an effect of treating or preventing breast cancer by inhibiting the cell proliferation of MCF-7, which is a human-derived breast cancer cell line. Thus, the composition is expected to be usefully used as a pharmaceutical composition for preventing or treating breast cancer using a mixture of salidroside and betulin, and as a functional food composition for alleviating or preventing breast cancer.
Inventors:
KIM JUNG YEAL (KR)
KIM YEWON (KR)
KIM YEWON (KR)
Application Number:
PCT/KR2017/005437
Publication Date:
October 11, 2018
Filing Date:
May 25, 2017
Export Citation:
Assignee:
KIM JUNG YEAL (KR)
KIM YEWON (KR)
KIM YEWON (KR)
International Classes:
A61K31/7032; A23L33/10; A61K31/56
Other References:
KROL, S. K. ET AL.: "Comprehensive Review on Betulin as a Potent Anticancer Agent", BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, pages 1 - 11, XP055559841
ZHAO, G. ET AL.: "Salidroside Inhibits the Growth of Human Breast Cancer in Vitro and in Vivo", ONCOLOGY REPORTS, vol. 33, 2015, pages 2553 - 2560, XP055559844
DAMLE, A. A. ET AL.: "Anticancer Activity of Betulinic Acid on MCF-7 Tumors in Nude Mice", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 51, no. 7, 2013, pages 485 - 491, XP055559854
LU , D. ET AL.: "The Study of Cytostatic Effect on MCF-7 Cells of the Alcohol Extract of Rhodiola Algida Var. Tangutica", PROCEDIA ENVIRONMENTAL SCIENCES, vol. 8, 2011, pages 615 - 619, XP028338647
HU , X. ET AL.: "Salidroside Induces Cell -cycle Arrest and Apoptosis in Human Breast Cancer Cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 398, no. 1, 2010, pages 62 - 67, XP027298193
ZHAO, G. ET AL.: "Salidroside Inhibits the Growth of Human Breast Cancer in Vitro and in Vivo", ONCOLOGY REPORTS, vol. 33, 2015, pages 2553 - 2560, XP055559844
DAMLE, A. A. ET AL.: "Anticancer Activity of Betulinic Acid on MCF-7 Tumors in Nude Mice", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 51, no. 7, 2013, pages 485 - 491, XP055559854
LU , D. ET AL.: "The Study of Cytostatic Effect on MCF-7 Cells of the Alcohol Extract of Rhodiola Algida Var. Tangutica", PROCEDIA ENVIRONMENTAL SCIENCES, vol. 8, 2011, pages 615 - 619, XP028338647
HU , X. ET AL.: "Salidroside Induces Cell -cycle Arrest and Apoptosis in Human Breast Cancer Cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 398, no. 1, 2010, pages 62 - 67, XP027298193
Attorney, Agent or Firm:
LEE, Sung Woo (KR)
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