Title:
COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE VALVULAR DISEASE COMPRISING PAD INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/035035
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating a degenerative valvular disease such as aortic stenosis, and has been completed by confirming that, when protein-arginine deiminase (PAD) proteins are inhibited in valve cells derived from an aortic stenosis patient, calcification or osteogenic differentiation, fibrosis, inflammation, etc., are effectively inhibited. That is, according to the present invention, calcification or osteogenic differentiation, fibrosis, and inflammation of valve tissue, which are the major pathological mechanisms for degenerative valvular disease, are simultaneously inhibited, thus enabling the fundamental treatment or prevention of progress of degenerative valvular disease. Therefore, the present invention is expected to be available as a therapeutic agent for various diseases caused by degenerative deformation of valves.
Inventors:
LEE SAHMIN (KR)
JI EUNHYE (KR)
JI EUNHYE (KR)
Application Number:
PCT/KR2023/011582
Publication Date:
February 15, 2024
Filing Date:
August 07, 2023
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
A61K48/00; A61K31/713; A61P9/00
Domestic Patent References:
| WO2018178935A1 | 2018-10-04 |
Foreign References:
| US20180136232A1 | 2018-05-17 |
Other References:
KNIGHT JASON S., LUO WEI, O’DELL ALEXANDER A., YALAVARTHI SRILAKSHMI, ZHAO WENPU, SUBRAMANIAN VENKATARAMAN, GUO CHIAO, GRENN ROBER: "Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis", CIRCULATION RESEARCH, vol. 114, no. 6, 14 March 2014 (2014-03-14), US , pages 947 - 956, XP093140063, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.114.303312
DÖRING YVONNE, LIBBY PETER, SOEHNLEIN OLIVER: "Neutrophil Extracellular Traps Participate in Cardiovascular Diseases : Recent Experimental and Clinical Insights", CIRCULATION RESEARCH, vol. 126, no. 9, 24 April 2020 (2020-04-24), US , pages 1228 - 1241, XP093140084, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.120.315931
LING SHUANG, XU JIN-WEN: "NETosis as a Pathogenic Factor for Heart Failure", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2021, 23 February 2021 (2021-02-23), US , pages 1 - 24, XP093140101, ISSN: 1942-0900, DOI: 10.1155/2021/6687096
DÖRING YVONNE, LIBBY PETER, SOEHNLEIN OLIVER: "Neutrophil Extracellular Traps Participate in Cardiovascular Diseases : Recent Experimental and Clinical Insights", CIRCULATION RESEARCH, vol. 126, no. 9, 24 April 2020 (2020-04-24), US , pages 1228 - 1241, XP093140084, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.120.315931
LING SHUANG, XU JIN-WEN: "NETosis as a Pathogenic Factor for Heart Failure", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2021, 23 February 2021 (2021-02-23), US , pages 1 - 24, XP093140101, ISSN: 1942-0900, DOI: 10.1155/2021/6687096
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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