Title:
COMPOSITION FOR PREVENTING OR TREATING DEMENTIA, CONTAINING PEPTIDE NUCLEIC ACID COMPLEX AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/065919
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating dementia, containing a nucleic acid complex in which a carrier peptide nucleic acid and a bioactive peptide nucleic acid having a sequence for binding to a NLRP3 gene are complementarily bound. The nucleic acid complex according to the present invention has a blood-brain barrier penetration ability and can effectively inhibit expression and phosphorylation of the protein of the NLRP3 gene and tau, which a lower-level gene, and thus is useful in the prevention or treatment of dementia.
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Inventors:
PARK MIN-JUNG (KR)
KIM HYE JOO (KR)
YU JI-YEON (KR)
PARK HEE KYUNG (KR)
KIM HYE JOO (KR)
YU JI-YEON (KR)
PARK HEE KYUNG (KR)
Application Number:
PCT/KR2021/013049
Publication Date:
March 31, 2022
Filing Date:
September 24, 2021
Export Citation:
Assignee:
SEASUN THERAPEUTICS (KR)
International Classes:
A61K48/00; A61K31/7088; A61K47/54; A61K47/64; A61P25/28
Foreign References:
| JP2018537528A | 2018-12-20 | |||
| KR20190096148A | 2019-08-19 | |||
| KR20180018405A | 2018-02-21 | |||
| JP2008220366A | 2008-09-25 | |||
| KR2017008636W | 2017-08-09 | |||
| KR20190128465A | 2019-11-18 |
Other References:
ARUMAY PAL, KURT NEO, LAKSHMINARAYANAN RAJAMANI, FERNANDO JOSE FERRER, DAVID P. LANE, CHANDRA S. VERMA, ALESSANDRA MORTELLARO: "Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides", SCIENTIFIC REPORTS, vol. 9, no. 1, 1 December 2019 (2019-12-01), XP055705458, DOI: 10.1038/s41598-019-41211-3
SELKOE, PHYSIOL REV, vol. 81, 2001, pages 741 - 66
ISING, C.VENEGAS, C.ZHANG, S. ET AL.: "NLRP3 inflammasome activation drives tau pathology", NATURE, vol. 575, 2019, pages 669 - 673, XP036953751, DOI: 10.1038/s41586-019-1769-z
KOLE R ET AL., NATURE REV. DRUG DISCOV., vol. 11, 2012, pages 125
WILSON C ET AL., CURR. OPIN. CHEM. BIO., vol. 10, 2006, pages 607
D. W. PACKA. S. HOFFMANS. PUNP. S. STAYTON: "Design and development of polymers for gene delivery", NAT., vol. 4, 2005, pages 581 - 593, XP037925365, DOI: 10.1038/nrd1775
SELKOE, PHYSIOL REV, vol. 81, 2001, pages 741 - 66
ISING, C.VENEGAS, C.ZHANG, S. ET AL.: "NLRP3 inflammasome activation drives tau pathology", NATURE, vol. 575, 2019, pages 669 - 673, XP036953751, DOI: 10.1038/s41586-019-1769-z
KOLE R ET AL., NATURE REV. DRUG DISCOV., vol. 11, 2012, pages 125
WILSON C ET AL., CURR. OPIN. CHEM. BIO., vol. 10, 2006, pages 607
D. W. PACKA. S. HOFFMANS. PUNP. S. STAYTON: "Design and development of polymers for gene delivery", NAT., vol. 4, 2005, pages 581 - 593, XP037925365, DOI: 10.1038/nrd1775
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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