Title:
COMPOSITION FOR PREVENTING OR TREATING DISEASES CAUSED BY MITOCHONDRIAL DYSFUNCTION, CONTAINING ISOQUINOLINE DERIVATIVE COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/225108
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing, as an active ingredient, an isoquinoline derivative compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof, and does not induce mitochondrial damage, unlike conventional mitochondrial toxins such as CCCP, and specifically and excellently promotes the activity of mitophagy to alleviate mitochondrial abnormality, and thus can be effectively used in the treatment of diseases caused by mitochondrial dysfunction.
Inventors:
YUN JEAN HO (KR)
CHO JONG HYUN (KR)
UM JEE HYUN (KR)
SHIN DONG JIN (KR)
CHOI SE MYEONG (KR)
CHO JONG HYUN (KR)
UM JEE HYUN (KR)
SHIN DONG JIN (KR)
CHOI SE MYEONG (KR)
Application Number:
PCT/KR2021/011911
Publication Date:
October 27, 2022
Filing Date:
September 03, 2021
Export Citation:
Assignee:
ALTMEDICALCO LTD (KR)
International Classes:
A23L33/10; A61K31/4745; A61P25/14; A61P25/28; C07D455/03
Domestic Patent References:
| WO2019002936A2 | 2019-01-03 |
Foreign References:
| US20100120810A1 | 2010-05-13 | |||
| KR20000048847A | 2000-07-25 |
Other References:
CHUNHUI ZHAO, SU PING, LV CUI, GUO LIMIN, CAO GUOQIONG, QIN CHUNXIA, ZHANG WENSHENG: "Berberine Alleviates Amyloid β -Induced Mitochondrial Dysfunction and Synaptic Loss", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, HINDAWI PUBLISHING CORPORATION, US, vol. 2019, 2 May 2019 (2019-05-02), US , pages 1 - 11, XP055770610, ISSN: 1942-0900, DOI: 10.1155/2019/7593608
THOMAS FRIEDEMANN, SCHUMACHER UDO, TAO YI, LEUNG ALEXANDER KAI-MAN, SCHRöDER SVEN: "Neuroprotective Activity of Coptisine from Coptis chinensis (Franch)", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, OXFORD UNIVERSITY PRESS, US, vol. 2015, 2 July 2015 (2015-07-02), US , pages 1 - 9, XP055770620, ISSN: 1741-427X, DOI: 10.1155/2015/827308
THOMAS FRIEDEMANN, SCHUMACHER UDO, TAO YI, LEUNG ALEXANDER KAI-MAN, SCHRöDER SVEN: "Neuroprotective Activity of Coptisine from Coptis chinensis (Franch)", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, OXFORD UNIVERSITY PRESS, US, vol. 2015, 2 July 2015 (2015-07-02), US , pages 1 - 9, XP055770620, ISSN: 1741-427X, DOI: 10.1155/2015/827308
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
Download PDF: