Title:
COMPOSITION FOR PREVENTING OR TREATING EYE DISEASES COMPRISING MICROCOCCUS LUTEUS-DERIVED EXTRACELLULAR VESICLES
Document Type and Number:
WIPO Patent Application WO/2022/145656
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, ameliorating, or treating eye diseases, the composition containing Micrococcus luteus-derived vesicles as an active ingredient. The present inventors have confirmed that when the vesicles are administered orally, the vesicles pass through the blood-brain barrier (BBB) and are thereby delivered to the central nervous system including the retina. In addition, not only was treating epithelial cells and macrophages with the vesicles found to remarkably inhibit the secretion of inflammatory mediators by biological causal factors, but treating cells with the vesicles was found to inhibit the expression of NLRP3 protein by biological causal factors. Furthermore, administering the vesicles to rabbit models with eye diseases caused by oxidative stress was found to significantly suppress the onset of retinal degeneration caused by oxidative stress. Therefore, the Micrococcus luteus-derived vesicles according to the present invention can be used as a composition for preventing, ameliorating, or treating aging-related eye diseases and inflammatory eye diseases, and can also be useful for the development of medicines or functional health foods for preventing, ameliorating, or treating aging-related eye diseases and inflammatory eye diseases.
Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2021/014598
Publication Date:
July 07, 2022
Filing Date:
October 19, 2021
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
A61K35/74; A23L33/135; A61K9/00; A61P1/16; A61P11/00; A61P13/12; A61P25/28; A61P29/00; A61P35/00; A61P37/08
Foreign References:
| KR20190103962A | 2019-09-05 | |||
| US20150132366A1 | 2015-05-14 | |||
| KR101830058B1 | 2018-02-20 | |||
| KR20160073157A | 2016-06-24 | |||
| KR20200184337A | ||||
| KR20210138713A | 2021-11-19 |
Other References:
MEAD BEN; TOMAREV STANISLAV: "Extracellular vesicle therapy for retinal diseases", PROGRESS IN RETINAL AND EYE RESEARCH, OXFORD, GB, vol. 79, 10 March 2020 (2020-03-10), GB , XP086395690, ISSN: 1350-9462, DOI: 10.1016/j.preteyeres.2020.100849
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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