Title:
COMPOSITION FOR PREVENTING AND TREATING HORMONAL DISORDER OR ANDROPAUSE IN MALES, CONTAINING, AS ACTIVE INGREDIENT, COMBINATION OF COMPOUNDS COMPRISING FLAVONOID DERIVATIVES AND IRIDOID DERIVATIVES, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/168324
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing and treating hormonal disorders or andropause in males, containing, as an active ingredient, a herbal medicine extract comprising a combination of compounds comprising flavonoid derivatives and iridoid derivatives, and a use thereof.
In an experiment for measuring the effects of a combination comprising (a) monotropein, (b) kaempferol 3-glucoside and (c) quercetin 4'-glucoside (spiraeoside) on the weight of the testes by using an in vivo varicocele animal model, the weight of the left testis in a normal group to which a drug had been administered slightly increased over that of a normal group, and the weight of the left testis in a varicocele mouse group to which a drug had been administered significantly increased over that of a varicocele mouse group.
In addition, it has been confirmed that a varicocele mouse group to which a drug is administered has blood testosterone and antioxidant activity-related blood SOD and GSH-Px activities that remarkably increased over those of a varicocele mouse group, and thus the present invention can be effectively used in a pharmaceutical composition, a functional health food and a health supplement for the prevention and treatment of hormonal disorders or andropause in males.
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Inventors:
PARK JONG KWAN (KR)
Application Number:
PCT/KR2019/002333
Publication Date:
September 06, 2019
Filing Date:
February 26, 2019
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
A61K31/7048; A23L33/10; A23L33/125; A61K31/352; A61P5/28
Domestic Patent References:
| WO2001003687A2 | 2001-01-18 |
Foreign References:
| KR101787008B1 | 2017-10-20 | |||
| KR101787007B1 | 2017-10-18 |
Other References:
CIFTCI, O. ET AL.: "Quercetin prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced testicular damage in rats", ANDROLOGIA, vol. 44, 2012, pages 164 - 173
TAEPONGSORAT, LADACHART ET AL.: "Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats", ASIAN JOURNAL OF ANDROLOGY, vol. 10, no. 2, 2008, pages 249 - 258, XP055510466, doi:10.1111/j.1745-7262.2008.00306.x
TAEPONGSORAT, LADACHART ET AL.: "Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats", ASIAN JOURNAL OF ANDROLOGY, vol. 10, no. 2, 2008, pages 249 - 258, XP055510466, doi:10.1111/j.1745-7262.2008.00306.x
Attorney, Agent or Firm:
SHIN, Dong In (KR)
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