Title:
COMPOSITION FOR PREVENTING OR TREATING ISCHAEMIC HEART DISEASE COMPRISING, AS AN ACTIVE INGREDIENT, AGE-ALBUMIN SYNTHESIS OR SECRETION INHIBITOR FOR MONONUCLEAR PHAGOCYTE SYSTEM CELLS
Document Type and Number:
WIPO Patent Application WO/2013/070048
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating ischaemic heart disease comprising, as an active ingredient, an inhibitor that inhibits AGE-albumin synthesis or secretion in mononuclear phagocyte system cells whereby apoptosis is induced in myocardial cells following the onset of ischaemic heart disease, and the present invention also relates to a screening method for the inhibitor. The pharmaceutical composition for preventing or treating ischaemic heart disease of the present invention can be widely used to prevent or treat various forms of ischaemic heart disease and notably myocardial infarction because the pharmaceutical composition comprises, as an active ingredient, an AGE-albumin synthesis or secretion inhibitor for mononuclear phagocyte system cells and the pharmaceutical composition can therefore inhibit or reduce apoptosis induced from AGE-albumin.
Inventors:
LEE BONG HEE (KR)
BYUN KYUNG HEE (KR)
BYUN KYUNG HEE (KR)
Application Number:
PCT/KR2012/009526
Publication Date:
May 16, 2013
Filing Date:
November 12, 2012
Export Citation:
Assignee:
UNIV GACHON IND ACAD COOP FOUND (KR)
International Classes:
A61K39/395; A61K38/38; A61P9/00; A61P9/10
Foreign References:
| US5702704A | 1997-12-30 |
Other References:
ALESHIN, A. ET AL.: "RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model", AM. J. PHYSIOL. HEART CIRC. PHYSIOL., vol. 294, 2008, pages H1823 - H1832
NAKAGOMI, A. ET AL.: "Secondary preventive effects of a calcium antagonist for ischemic heart attack", CIRCULATION JOURNAL, vol. 75, 17 May 2011 (2011-05-17), pages 1696 - 1705
THOMAS, M. C. ET AL.: "The role of AGEs and AGE inhibitors in diabetic cardiovascular disease", CURRENT DRUG TARGETS, vol. 6, 2005, pages 453 - 474, XP008100559, DOI: doi:10.2174/1389450054021873
DUKIC-STEFANOVIC, S. ET AL.: "AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?", BIOGERONTOLOGY, vol. 2, 2001, pages 19 - 34
BIERHAUS, A. ET AL.: "Advanced glycation end product(AGE)-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE", CIRCULATION, vol. 96, 1997, pages 2262 - 2271
NAKAGOMI, A. ET AL.: "Secondary preventive effects of a calcium antagonist for ischemic heart attack", CIRCULATION JOURNAL, vol. 75, 17 May 2011 (2011-05-17), pages 1696 - 1705
THOMAS, M. C. ET AL.: "The role of AGEs and AGE inhibitors in diabetic cardiovascular disease", CURRENT DRUG TARGETS, vol. 6, 2005, pages 453 - 474, XP008100559, DOI: doi:10.2174/1389450054021873
DUKIC-STEFANOVIC, S. ET AL.: "AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?", BIOGERONTOLOGY, vol. 2, 2001, pages 19 - 34
BIERHAUS, A. ET AL.: "Advanced glycation end product(AGE)-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE", CIRCULATION, vol. 96, 1997, pages 2262 - 2271
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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Claims: