Title:
COMPOSITION FOR PREVENTING AND TREATING MALE INFERTILITY, CONTAINING FLAVONOID DERIVATIVE COMPOUND AS ACTIVE INGREDIENT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/105998
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing and treating male infertility, containing a flavonoid compound as an active ingredient. Through an in vitro sperm movement promoting effect evaluation method experiment for investigating the effect of the flavonoid derivative compound of the present invention on changes in the sperm count and mobility of human and porcine semen, it was confirmed that samples of the present invention show increased sperm mobility in the in vitro experiment with the human and porcine semen. Accordingly, the composition can be useful for a pharmaceutical composition, a health functional food and a health supplemental food for preventing and treating male infertility.
Inventors:
PARK JONG KWAN (KR)
Application Number:
PCT/KR2017/014176
Publication Date:
June 14, 2018
Filing Date:
December 06, 2017
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
A61K31/7048; A23L33/10; A61K31/352
Foreign References:
| KR100903581B1 | 2009-06-22 |
Other References:
TAEPONGSORAT, L. ET AL.: "Stimulating Effects of Quercetin on Sperm Quality and Reproductive Organs in Adult Male Rats", ASIAN J ANDROL, vol. 10, no. 2, March 2008 (2008-03-01), pages 249 - 258, XP055510466
NASS-ARDEN, L. ET AL.: "Modulation of Mammalian Sperm Motility by Quercetin", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 25, no. 4, April 1990 (1990-04-01), pages 369 - 373, XP001009971
KHAKI, A. ET AL.: "Beneficial Effects of Quercetin on Sperm Parameters in Streptozotocin-induced Diabetic Male Rats", PHYTOTHERAPY RESEARCH, vol. 24, no. 9, September 2010 (2010-09-01), pages 1285 - 1291, XP018503006
SONI, K. K. ET AL.: "The Effects of MOTILlPERM on Cisplatin Induced Testicular Toxicity in Sprague-Dawley Rats", CANCER CELL INTERNATIONAL, vol. 15, no. 121, December 2015 (2015-12-01), pages 1 - 11, XP055427029
NASS-ARDEN, L. ET AL.: "Modulation of Mammalian Sperm Motility by Quercetin", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 25, no. 4, April 1990 (1990-04-01), pages 369 - 373, XP001009971
KHAKI, A. ET AL.: "Beneficial Effects of Quercetin on Sperm Parameters in Streptozotocin-induced Diabetic Male Rats", PHYTOTHERAPY RESEARCH, vol. 24, no. 9, September 2010 (2010-09-01), pages 1285 - 1291, XP018503006
SONI, K. K. ET AL.: "The Effects of MOTILlPERM on Cisplatin Induced Testicular Toxicity in Sprague-Dawley Rats", CANCER CELL INTERNATIONAL, vol. 15, no. 121, December 2015 (2015-12-01), pages 1 - 11, XP055427029
Attorney, Agent or Firm:
SHIN, Dong In (KR)
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