Title:
COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY DISEASE COMPRISING DIDANOSINE
Document Type and Number:
WIPO Patent Application WO/2022/108381
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating a neuroinflammatory disease, which can inhibit the expression of neuroinflammatory cytokines, promote the degradation of amyloid beta, and improve a cognitive function in an animal model of Alzheimer's disease. More specifically, the present invention relates to a composition for preventing or treating a neuroinflammatory disease comprising didanosine or a pharmaceutically acceptable salt thereof, and the composition may be used for the development of drugs and quasi-drug materials.
Inventors:
YU SEONG-WOON (KR)
NAM HYERI (KR)
LEE YOUNGHWAN (KR)
NAM HYERI (KR)
LEE YOUNGHWAN (KR)
Application Number:
PCT/KR2021/017068
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
Assignee:
OATC INC (KR)
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
International Classes:
A61K31/522; A23L33/10; A61P25/00
Foreign References:
| US20180099939A1 | 2018-04-12 | |||
| KR20140134170A | 2014-11-21 |
Other References:
ZHU YU, VERGOTE DAVID, PARDO CARLOS, NOORBAKHSH FARSHID, MCARTHUR JUSTIN C., HOLLENBERG MORLEY D., OVERALL CHRISTOPHER M., POWER C: "CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy", THE FASEB JOURNAL, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 23, no. 9, 1 September 2009 (2009-09-01), US, pages 2928 - 2941, XP055931349, ISSN: 0892-6638, DOI: 10.1096/fj.08-128819
BRIAN GIUNTA;JARED EHRHART;DEMIAN F OBREGON;LUCY LAM;LISA LE;JINGJI JIN;FRANCISCO FERNANDEZ;JUN TAN;R DOUGLAS SHYTLE: "Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders", MOLECULAR BRAIN, BIOMED CENTRAL LTD, LONDON UK, vol. 4, no. 1, 7 June 2011 (2011-06-07), London UK , pages 23, XP021104351, ISSN: 1756-6606, DOI: 10.1186/1756-6606-4-23
SCHÜTZ SONJA G., JESSICA ROBINSON-PAPP: "HIV-related neuropathy: current perspectives", HIV/AIDS - RESEARCH AND PALLIATIVE CARE, vol. 5, 11 September 2013 (2013-09-11), pages 243 - 251, XP055931347, DOI: 10.2147/HIV.S36674
JIANG ET AL.: "4 Review of the Familial Alzheimer's Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 7", JOURNAL OF ALZHEIMER'S DISEASE, vol. 66, 2018, pages 1223 - 1339
CHO, M.-H ET AL.: "Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome", AUTOPHAGY, vol. 10, 2014, pages 1761 - 1775, XP055195951, DOI: 10.4161/auto.29647
JAWHAR S. ET AL.: "Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aft aggregation in the SXFAD mouse model of Alzheimer's disease", NEUROBIOLOGY OF AGING, vol. 196, 2012, pages e29 - 40
BRIAN GIUNTA;JARED EHRHART;DEMIAN F OBREGON;LUCY LAM;LISA LE;JINGJI JIN;FRANCISCO FERNANDEZ;JUN TAN;R DOUGLAS SHYTLE: "Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders", MOLECULAR BRAIN, BIOMED CENTRAL LTD, LONDON UK, vol. 4, no. 1, 7 June 2011 (2011-06-07), London UK , pages 23, XP021104351, ISSN: 1756-6606, DOI: 10.1186/1756-6606-4-23
SCHÜTZ SONJA G., JESSICA ROBINSON-PAPP: "HIV-related neuropathy: current perspectives", HIV/AIDS - RESEARCH AND PALLIATIVE CARE, vol. 5, 11 September 2013 (2013-09-11), pages 243 - 251, XP055931347, DOI: 10.2147/HIV.S36674
JIANG ET AL.: "4 Review of the Familial Alzheimer's Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 7", JOURNAL OF ALZHEIMER'S DISEASE, vol. 66, 2018, pages 1223 - 1339
CHO, M.-H ET AL.: "Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome", AUTOPHAGY, vol. 10, 2014, pages 1761 - 1775, XP055195951, DOI: 10.4161/auto.29647
JAWHAR S. ET AL.: "Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aft aggregation in the SXFAD mouse model of Alzheimer's disease", NEUROBIOLOGY OF AGING, vol. 196, 2012, pages e29 - 40
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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