Title:
COMPOSITION FOR PREVENTING OR TREATING NEUROPATHIC PAIN, COMPRISING GCH1-TARGETING SIRNA AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/106815
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating neuropathic pain, the composition comprising GCH1-targeting siRNA as an active ingredient. The present inventors selected target sequences from conserved sequence patterns in various species of GCH1, designed 10 types of siRNA in the confirmed conserved sequence patterns, and selected 3 types of siRNA candidates with good efficacy from among the 10 types of designed siRNA. It was confirmed that the GCH1-targeting siRNA according to the present invention has the effect of inhibiting the mRNA and protein expression of GCH1 and thereby also reducing the concentration of BH4, a neurotransmitter produced by GCH1. Accordingly, the GCH1-targeting siRNA according to the present invention inhibits GCH1 overexpressed in a patient with neuropathic pain and thus can be effectively used as a pain control therapeutic agent.
Inventors:
KIM JIHYUN (KR)
WOO HA-NA (KR)
LEE KYOUNG JIN (KR)
LEE HEUIRAN (KR)
WOO HA-NA (KR)
LEE KYOUNG JIN (KR)
LEE HEUIRAN (KR)
Application Number:
PCT/KR2023/017457
Publication Date:
May 23, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
UNIV ULSAN FOUND IND COOP (KR)
ASAN FOUND (KR)
ASAN FOUND (KR)
International Classes:
A61K48/00; A23L33/13; A61K31/713; A61P25/04; A61P29/00
Foreign References:
| KR20110132307A | 2011-12-07 | |||
| US20220211871A1 | 2022-07-07 | |||
| US20170035860A1 | 2017-02-09 |
Other References:
DATABASE Nucleotide 12 February 2021 (2021-02-12), ANONYMOUS: "PREDICTED: Saimiri boliviensis boliviensis GTP cyclohydrolase 1 (GCH1), mRNA", XP093169508, Database accession no. XM_003930511.3
KIM SUNG JIN; LEE WON IL; LEE YOON SUN; KIM DONG HOU; CHANG JIN WOO; KIM SEONG WHO; LEE HEUIRAN: "Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1", MOLECULAR PAIN, BIOMED CENTRAL, LONDON, GB, vol. 5, no. 1, 18 November 2009 (2009-11-18), GB , pages 67, XP021064372, ISSN: 1744-8069, DOI: 10.1186/1744-8069-5-67
KIM SUNG JIN; LEE WON IL; LEE YOON SUN; KIM DONG HOU; CHANG JIN WOO; KIM SEONG WHO; LEE HEUIRAN: "Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1", MOLECULAR PAIN, BIOMED CENTRAL, LONDON, GB, vol. 5, no. 1, 18 November 2009 (2009-11-18), GB , pages 67, XP021064372, ISSN: 1744-8069, DOI: 10.1186/1744-8069-5-67
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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