Title:
COMPOSITION FOR PREVENTING OR TREATING NEUROPSYCHOLOGIC DISEASE, COMPRISING MANF
Document Type and Number:
WIPO Patent Application WO/2022/071752
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating a neuropsychologic disease, the composition comprising a mesencephalic growth factor (mesencephalic, astrocyte-derived neurotrophic factor; MANF), a peptide derived therefrom, or a fragment of the peptide. Administering the MANF according to the present invention promotes the differentiation of cholinergic and/or γ-aminobutyric acid (GABA)ergic neurons in models of memory impairment and autism, thereby inducing nerve regeneration, has the effects of improving memory and ameliorating emotional insecurity, and improves deficiencies in social awareness, sociability, and social and sexual preference. Therefore, the composition can be provided as a composition for preventing or treating neuropsychologic diseases such as autism, ADHD, intellectual disability, and developmental disability.
Inventors:
KIM YUNHEE (KR)
LEE HYEMI (KR)
KWON HYOCKMAN (KR)
LEE HYEMI (KR)
KWON HYOCKMAN (KR)
Application Number:
PCT/KR2021/013342
Publication Date:
April 07, 2022
Filing Date:
September 29, 2021
Export Citation:
Assignee:
CEFO CO LTD (KR)
International Classes:
A61K38/18; A23K20/147; A23L33/17; A23L33/18; A61P25/00; A61P25/18
Foreign References:
| EP2271358B1 | 2018-11-21 | |||
| US20150020222A1 | 2015-01-15 | |||
| CN109675019A | 2019-04-26 | |||
| US20190142765A1 | 2019-05-16 |
Other References:
XU SHENGCHUN, DI ZEMIN, HE YUFENG, WANG RUNJIE, MA YUYANG, SUN RUI, LI JING, WANG TAO, SHEN YUJUN, FANG SHENGYUN, FENG LIJIE, SHEN: "Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress", JOURNAL OF NEUROINFLAMMATION, vol. 16, no. 1, 1 December 2019 (2019-12-01), XP055918089, DOI: 10.1186/s12974-019-1429-0
HOUTARINEN ANTTI, ANNA-MAIJA PENTTINEN, SUSANNE BÄCK, MERJA H VOUTILAINEN, ULRIKA JULKU, T PETTERI PIEPPONEN, PEKKA T MÄNNISTÖ, MA: "Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson’s Disease", NEUROSCIENCE, vol. 374, 3 February 2018 (2018-02-03), pages 250 - 263, XP055918090, DOI: 10.1016/j.neuroscience.2018.01.052
KARLINALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
F.M. AUSUBEL ET AL., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY
MIYUKI SADAMATSU: "Review of animal models for autism: implication of thyroid hormone", CONGENITAL ANOMALIES, vol. 46, 2006, pages 1 - 9, XP071783889, DOI: 10.1111/j.1741-4520.2006.00094.x
HOUTARINEN ANTTI, ANNA-MAIJA PENTTINEN, SUSANNE BÄCK, MERJA H VOUTILAINEN, ULRIKA JULKU, T PETTERI PIEPPONEN, PEKKA T MÄNNISTÖ, MA: "Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson’s Disease", NEUROSCIENCE, vol. 374, 3 February 2018 (2018-02-03), pages 250 - 263, XP055918090, DOI: 10.1016/j.neuroscience.2018.01.052
KARLINALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
F.M. AUSUBEL ET AL., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY
MIYUKI SADAMATSU: "Review of animal models for autism: implication of thyroid hormone", CONGENITAL ANOMALIES, vol. 46, 2006, pages 1 - 9, XP071783889, DOI: 10.1111/j.1741-4520.2006.00094.x
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
Download PDF: