COMPOSITION FOR PREVENTING OR TREATING PERIPHERAL NEUROPATHY, CONTAINING ISOQUINOLINE DERIVATIVE AS ACTIVE INGREDIENT

WIPO Patent Application WO/2024/080768

A1

The present invention relates to a pharmaceutical composition for preventing or treating peripheral neuropathy, and the like. The present invention has been completed by confirming that an isoquinoline derivative discovered through a screening based on mitophage activity exhibits an excellent mitophage promoting effect, and thus, the isoquinoline derivative can be utilized as a fundamental therapeutic agent for peripheral neuropathy. Specifically, it has been found that the isoquinoline derivative according to the present invention treats hyperalgesia in an animal model of anticancer drug-inducible peripheral neuropathy, also suppresses morphological changes of sensory nerves, which have been identified as a key cause of peripheral neuropathy, and can increase the distribution and number of peripheral nerves. Therefore, the isoquinoline derivative according to the present invention is a fundamental therapeutic agent capable of suppressing the main symptoms and causes of peripheral neuropathy, particularly, anticancer drug-induced peripheral neuropathy, and is expected to be usefully utilized in the field of prevention, amelioration, and/or treatment of the disease.

YUN JEANHO (KR)
CHO JONG HYUN (KR)
LEE JI HYUN (KR)
IM SANGWOO (KR)
CHOI SE MYEONG (KR)

PCT/KR2023/015689

April 18, 2024

October 12, 2023

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ALTMEDICAL CO LTD (KR)
DONG A UNIV RESEARCH FOUNDATION FOR INDUSTRY ACADEMY COOPERATION (KR)

A61K31/4745; A23L33/10; A61P25/02

LEE, Myoung-Jin (KR)

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