Title:
COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS, COMPRISING TAURODEOXYCHOLIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/195798
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating pulmonary fibrosis, comprising taurodeoxycholic acid or a pharmaceutically acceptable salt thereof as an active ingredient. More particularly, it was confirmed that pulmonary fibrosis and the expression of pulmonary fibrosis-related factors are reduced in an idiopathic pulmonary fibrosis animal model and a pulmonary fibrosis cell model that are administered with a pharmaceutically acceptable salt of taurodeoxycholic acid, and thus the taurodeoxycholic acid or a pharmaceutically acceptable salt thereof can be used as an active ingredient in the composition for preventing or treating pulmonary fibrosis.
Inventors:
SEONG SEUNG YONG (KR)
HWANG JEONG JUNG (KR)
HWANG JEONG JUNG (KR)
Application Number:
PCT/KR2023/004665
Publication Date:
October 12, 2023
Filing Date:
April 06, 2023
Export Citation:
Assignee:
SHAPERON INC (KR)
International Classes:
A61K31/575; A23L33/10; A61P11/00; A61P43/00
Domestic Patent References:
| WO2006134022A1 | 2006-12-21 | |||
| WO2020176703A1 | 2020-09-03 | |||
| WO2011157655A1 | 2011-12-22 |
Other References:
BIN TONG;LIN FU;BIAO HU;ZHI-CHENG ZHANG;ZHU-XIA TAN;SE-RUO LI;YUAN-HUA CHEN;CHENG ZHANG;HUA WANG;DE-XIANG XU;HUI ZHAO: "Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis", BMC PULMONARY MEDICINE, vol. 21, no. 1, 5 May 2021 (2021-05-05), London, UK , pages 1 - 11, XP021290437, DOI: 10.1186/s12890-021-01514-6
HORVATITS THOMAS, DROLZ ANDREAS, RUTTER KAROLINE, ROEDL KEVIN, LANGOUCHE LIES, VAN DEN BERGHE GREET, FAULER GÜNTER, MEYER BRIGITTE: "Circulating bile acids predict outcome in critically ill patients", ANNALS OF INTENSIVE CARE, vol. 7, no. 1, 1 December 2017 (2017-12-01), pages 1 - 10, XP093097916, DOI: 10.1186/s13613-017-0272-7
HORVATITS THOMAS, DROLZ ANDREAS, RUTTER KAROLINE, ROEDL KEVIN, LANGOUCHE LIES, VAN DEN BERGHE GREET, FAULER GÜNTER, MEYER BRIGITTE: "Circulating bile acids predict outcome in critically ill patients", ANNALS OF INTENSIVE CARE, vol. 7, no. 1, 1 December 2017 (2017-12-01), pages 1 - 10, XP093097916, DOI: 10.1186/s13613-017-0272-7
Attorney, Agent or Firm:
KIM, Bo Jung (KR)
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