Title:
COMPOSITION FOR PREVENTING OR TREATING STEATOSIS, COMPRISING AXL
Document Type and Number:
WIPO Patent Application WO/2023/101316
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating steatosis, a diagnostic composition, and an information provision method for diagnosis. The expression and activity of AXL, which is a marker of the present invention, are regulated, and thus it is expected that AXL is effectively used in the development of a therapeutic agent for steatosis.
Inventors:
PARK JONGSUN (KR)
LEE HYUNJI (KR)
LEE HYUNJI (KR)
Application Number:
PCT/KR2022/018680
Publication Date:
June 08, 2023
Filing Date:
November 24, 2022
Export Citation:
Assignee:
IAC IN NAT UNIV CHUNGNAM (KR)
International Classes:
A61K38/45; A61P1/16; A61P3/00; C12Q1/6883; G01N33/68
Foreign References:
| US20030157573A1 | 2003-08-21 | |||
| KR20170134641A | 2017-12-06 |
Other References:
LEE HYUN-JI: "The role and function ofAXL, a new target of obese fatty liver", CHUNGNAM NATIONAL UNIVERSITY HOSPITAL NEWSLETTER - HAPPY KEEPER, 1 January 2021 (2021-01-01), XP093070508, Retrieved from the Internet
BHAVE SAYALI, HO HAN KIAT: "Exploring the Gamut of Receptor Tyrosine Kinases for Their Promise in the Management of Non-Alcoholic Fatty Liver Disease", BIOMEDICINES, vol. 9, no. 12, pages 1776, XP093070510, DOI: 10.3390/biomedicines9121776
TUTUSAUS ANNA, DE GREGORIO ESTEFANÍA, CUCARULL BLANCA, CRISTÓBAL HELENA, ARESTÉ CRISTINA, GRAUPERA ISABEL, COLL MAR, COLELL ANNA, : "A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target", CMGH CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, vol. 9, no. 3, 1 January 2020 (2020-01-01), pages 349 - 368, XP093070513, ISSN: 2352-345X, DOI: 10.1016/j.jcmgh.2019.10.010
ZHU CHENJING, WEI YUQUAN, WEI XIAWEI: "AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications", MOLECULAR CANCER, BMC, vol. 18, no. 1, 1 December 2019 (2019-12-01), pages 153, XP093013311, DOI: 10.1186/s12943-019-1090-3
BHAVE SAYALI, HO HAN KIAT: "Exploring the Gamut of Receptor Tyrosine Kinases for Their Promise in the Management of Non-Alcoholic Fatty Liver Disease", BIOMEDICINES, vol. 9, no. 12, pages 1776, XP093070510, DOI: 10.3390/biomedicines9121776
TUTUSAUS ANNA, DE GREGORIO ESTEFANÍA, CUCARULL BLANCA, CRISTÓBAL HELENA, ARESTÉ CRISTINA, GRAUPERA ISABEL, COLL MAR, COLELL ANNA, : "A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target", CMGH CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, vol. 9, no. 3, 1 January 2020 (2020-01-01), pages 349 - 368, XP093070513, ISSN: 2352-345X, DOI: 10.1016/j.jcmgh.2019.10.010
ZHU CHENJING, WEI YUQUAN, WEI XIAWEI: "AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications", MOLECULAR CANCER, BMC, vol. 18, no. 1, 1 December 2019 (2019-12-01), pages 153, XP093013311, DOI: 10.1186/s12943-019-1090-3
Attorney, Agent or Firm:
WON, Dae Gyu (KR)
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