Title:
COMPOSITION FOR PREVENTION, ALLEVIATION, OR TREATMENT OF NEURODEGENERATIVE DISEASES, COMPRISING FEXOFENADINE
Document Type and Number:
WIPO Patent Application WO/2024/035015
Kind Code:
A1
Abstract:
The present invention relates to a composition for prevention, alleviation, or treatment of neurodegenerative diseases, comprising fexofenadine. Fexofenadine, a compound already commercialized for pharmacological purposes, has proven to be safe, demonstrated significant improvements in behavioral abilities when administered to a neurodegenerative disease model, and exhibits neuroprotective effects of inhibiting the death of dopaminergic neurons, reducing damage to inflammation-mediated neurons or neuronal degeneration, preventing the formation of alpha-synuclein aggregates, and suppressing the abnormal increase and activation of astrocytes, and has the effect of extending the lifespan in the degenerative neurological disease model. Thus, the composition according to the present invention can be advantageously used for preventing, alleviating, or treating neurodegenerative diseases.
Inventors:
PARK SANG MYUN (KR)
YOON DUK YONG (KR)
KIM SOOJEONG (KR)
HA TAE YOUNG (KR)
KIM JAE BONG (KR)
KIM DONGKYU (KR)
KIM YUJEONG (KR)
SO MINYOUNG (KR)
KOO HEE JUNG (KR)
HAN DAEHEE (KR)
YOON DUK YONG (KR)
KIM SOOJEONG (KR)
HA TAE YOUNG (KR)
KIM JAE BONG (KR)
KIM DONGKYU (KR)
KIM YUJEONG (KR)
SO MINYOUNG (KR)
KOO HEE JUNG (KR)
HAN DAEHEE (KR)
Application Number:
PCT/KR2023/011489
Publication Date:
February 15, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
STANDIGM INC (KR)
STANDIGM INC (KR)
International Classes:
A61K31/445; A23L33/10; A61P25/28
Foreign References:
| CN105456265A | 2016-04-06 | |||
| KR20170093737A | 2017-08-16 |
Other References:
RAO JAGADEESH, CHIAPPELLI JOSHUA, KOCHUNOV PETER, REGENOLD WILLIAM T., RAPOPORT STANLEY I., HONG L. ELLIOT: "Is Schizophrenia a Neurodegenerative Disease? Evidence from Age-Related Decline of Brain-Derived Neurotrophic Factor in the Brains of Schizophrenia Patients and Matched Nonpsychiatric Controls", NEURODEGENERATIVE DISEASES, KARGER, CH, vol. 15, no. 1, 1 January 2015 (2015-01-01), CH , pages 38 - 44, XP093138792, ISSN: 1660-2854, DOI: 10.1159/000369214
ERIKSSON, U. K. ET AL.: "Asthma, Eczema, Rhinitis and the Risk for Dementia", DEMENT. GERIATR. COGN. DISORD., vol. 25, 2008, pages 148 - 156
MELTZER ELI O., ROSARIO NELSON AUGUSTO, VAN BEVER HUGO, LUCIO LUIZ: "Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis", ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY, BIOMED CENTRAL LTD, LONDON, UK, vol. 17, no. 1, London, UK , XP093138796, ISSN: 1710-1492, DOI: 10.1186/s13223-021-00614-6
ERIKSSON, U. K. ET AL.: "Asthma, Eczema, Rhinitis and the Risk for Dementia", DEMENT. GERIATR. COGN. DISORD., vol. 25, 2008, pages 148 - 156
MELTZER ELI O., ROSARIO NELSON AUGUSTO, VAN BEVER HUGO, LUCIO LUIZ: "Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis", ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY, BIOMED CENTRAL LTD, LONDON, UK, vol. 17, no. 1, London, UK , XP093138796, ISSN: 1710-1492, DOI: 10.1186/s13223-021-00614-6
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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