Title:
COMPOSITION FOR PREVENTION OR TREATMENT OF OSTEOARTHRITIS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/244016
Kind Code:
A1
Abstract:
The present invention relates to novel long non-coding RNAs (lncRNA) involved in the regulation of chondrocyte hypertrophy. Together with the finding that RUNX2 was regulated at the post-translational level during the hypertrophic differentiation of the chondrocyte cell line TC28a2, the discovery of two novel RUNX2 binding lncRNAs among many long non-coding RNAs led to the present invention. Bone-related diseases can be diagnosed by measuring the expression of the specific lncRNAs discovered. Furthermore, suppression against the expression of the specific lncRNAs discovered can induce chondrocyte hypertrophy, thus effectively inhibiting the vascularization or calcification of joint cartilage. This suggests a highly effective application in the prevention or treatment of bone-related diseases.
Inventors:
KIM SUNG-HWAN (KR)
LEE JIN WOO (KR)
YOON DONG SUK (KR)
LEE JIN WOO (KR)
YOON DONG SUK (KR)
Application Number:
PCT/KR2023/008204
Publication Date:
December 21, 2023
Filing Date:
June 14, 2023
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
C12Q1/6883; A61K31/7088; A61K48/00; A61P19/00
Foreign References:
| KR20220061033A | 2022-05-12 | |||
| JP2022041601A | 2022-03-11 | |||
| CN112063710A | 2020-12-11 |
Other References:
"Master's thesis", 1 February 2021, THE GRADUATE SCHOOL, YONSEI UNIVERSITY, Korea, article JOUNG, SOYEONG: "Identification of novel long noncoding RNA associated with chondrocyte hypertrophy", pages: 1 - 71, XP009551339
TAVALLAEE GHAZALEH: "Role of microRNA-27b-3p in the Regulation of Key Extracellular Matrix Markers in the Synovium During Osteoarthritis", PHD THESIS, PROQUEST DISSERTATIONS PUBLISHING, 1 June 2020 (2020-06-01), XP093118325, ISBN: 979-8-6623-9236-6, Retrieved from the Internet [retrieved on 20240111]
YOON DONG SUK, KIM EUN-JI, CHO SEHEE, JUNG SOYEONG, LEE KYOUNG-MI, PARK KWANG HWAN, LEE JIN WOO, KIM SUNG-HWAN: "RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 19, no. 1, 1 January 2023 (2023-01-01), pages 13 - 33, XP093118328, ISSN: 1449-2288, DOI: 10.7150/ijbs.74895
TAVALLAEE GHAZALEH: "Role of microRNA-27b-3p in the Regulation of Key Extracellular Matrix Markers in the Synovium During Osteoarthritis", PHD THESIS, PROQUEST DISSERTATIONS PUBLISHING, 1 June 2020 (2020-06-01), XP093118325, ISBN: 979-8-6623-9236-6, Retrieved from the Internet
YOON DONG SUK, KIM EUN-JI, CHO SEHEE, JUNG SOYEONG, LEE KYOUNG-MI, PARK KWANG HWAN, LEE JIN WOO, KIM SUNG-HWAN: "RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 19, no. 1, 1 January 2023 (2023-01-01), pages 13 - 33, XP093118328, ISSN: 1449-2288, DOI: 10.7150/ijbs.74895
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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