Title:
COMPOSITION FOR PROMOTING PRODUCTION OF STEM CELL-DERIVED EXOSOMES AND INCREASING STEMNESS
Document Type and Number:
WIPO Patent Application WO/2020/251181
Kind Code:
A1
Abstract:
The present invention relates to a composition for promoting the production of stem cell-derived exosomes or increasing the stemness of stem cells. When the composition of the present invention is used in culturing stem cells, the stemness of stem cells and the yield of stem cell-derived exosomes are increased, and thus good-quality stem cells and stem cell-derived exosomes can be produced more efficiently, and accordingly, can be advantageously used in related research and development and commercialization.
Inventors:
KIM SUE (KR)
LEE SEULKI (KR)
KIM JIMIN (KR)
LEE SEULKI (KR)
KIM JIMIN (KR)
Application Number:
PCT/KR2020/006574
Publication Date:
December 17, 2020
Filing Date:
May 20, 2020
Export Citation:
Assignee:
BREXOGEN INC (KR)
International Classes:
C12N5/0775
Foreign References:
| KR20120058866A | 2012-06-08 |
Other References:
VARKOUHI, AMIR K., JERKIC MIRJANA, ORMESHER LINDSAY, GAGNON STÉPHANE, GOYAL SAKSHI, RABANI RAZIEH, MASTERSON CLAIRE, SPRING CHRIS,: "Extracellular vesicles from interferon-y-primed human umbilical cord mesenchymal stromal cells reduce Escherichia coli-induced acute lung injury in rats", ANESTHESIOLOGY, vol. 130, no. 5, May 2019 (2019-05-01), pages 778 - 790, XP055769839, DOI: 10.1097/ALN.0000000000002655
MORALES-MANTILLA, D. E.: "The role of interferon-gamma in hematopoietic stem cell development, homeostasis, and disease", CURRENT STEM CELL REPORTS, vol. 4, no. 3, 2018, pages 264 - 271, XP055769841, DOI: 10.1007/s40778-018-0139-3
CHAE, DONG-SIK, LEE CHANG YOUN, LEE JIYUN, SEO HYANG-HEE, CHOI CHONG-HYUK, LEE SEAHYOUNG, HWANG KI-CHUL: "Priming stem cells with protein kinase C activator enhances early stem cell -chondrocyte interaction by increasing adhesion molecules", BIOLOGICAL RESEARCH, vol. 51, 2018, pages 1 - 11, XP055769844, DOI: 10.1186/s40659-018-0191-6
GROTH, E.: "Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1863, 2016, pages 2795 - 2808, XP029742974, DOI: 10.1016/j.bbamcr.2016.09.002
ZHOU, HAO, LI DANDAN, SHI CHEN, XIN TING, YANG JUNJIE, ZHOU YING, HU SHUNYIN, TIAN FENG, WANG JING, CHEN YUNDAI: "Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro", SCIENTIFIC REPORTS, vol. 5, 2015, pages 1 - 14, XP055769848, DOI: 10.1038/srep12898
"Remington's Pharmaceutical Sciences", 1995
See also references of EP 3981871A4
MORALES-MANTILLA, D. E.: "The role of interferon-gamma in hematopoietic stem cell development, homeostasis, and disease", CURRENT STEM CELL REPORTS, vol. 4, no. 3, 2018, pages 264 - 271, XP055769841, DOI: 10.1007/s40778-018-0139-3
CHAE, DONG-SIK, LEE CHANG YOUN, LEE JIYUN, SEO HYANG-HEE, CHOI CHONG-HYUK, LEE SEAHYOUNG, HWANG KI-CHUL: "Priming stem cells with protein kinase C activator enhances early stem cell -chondrocyte interaction by increasing adhesion molecules", BIOLOGICAL RESEARCH, vol. 51, 2018, pages 1 - 11, XP055769844, DOI: 10.1186/s40659-018-0191-6
GROTH, E.: "Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1863, 2016, pages 2795 - 2808, XP029742974, DOI: 10.1016/j.bbamcr.2016.09.002
ZHOU, HAO, LI DANDAN, SHI CHEN, XIN TING, YANG JUNJIE, ZHOU YING, HU SHUNYIN, TIAN FENG, WANG JING, CHEN YUNDAI: "Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro", SCIENTIFIC REPORTS, vol. 5, 2015, pages 1 - 14, XP055769848, DOI: 10.1038/srep12898
"Remington's Pharmaceutical Sciences", 1995
See also references of EP 3981871A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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