Title:
COMPOSITION FOR REGENERATION OF INTERVERTEBRAL DISC
Document Type and Number:
WIPO Patent Application WO/2022/163872
Kind Code:
A1
Abstract:
Provided is a composition for promoting the regeneration of nucleus pulposus of intervertebral disc, said composition comprising a monovalent metal salt of a low endotoxin alginic acid and mesenchymal stem cells. In particular, the composition according to the present invention promotes the regeneration of nucleus pulposus of intervertebral disc via the activation of nucleus pulposus cells by human bone marrow-derived high-purity mesenchymal stem cells and/or the differentiation of human bone marrow-derived high-purity mesenchymal stem cells into nucleus pulposus cells.
Inventors:
SUDO HIDEKI (JP)
UKEBA DAISUKE (JP)
YAMADA KATSUHISA (JP)
URA KATSURO (JP)
SUZUKI HISATAKA (JP)
IYOKU YUMI (JP)
SUYAMA TAKASHI (JP)
UKEBA DAISUKE (JP)
YAMADA KATSUHISA (JP)
URA KATSURO (JP)
SUZUKI HISATAKA (JP)
IYOKU YUMI (JP)
SUYAMA TAKASHI (JP)
Application Number:
PCT/JP2022/004342
Publication Date:
August 04, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
PUREC CO LTD (JP)
MOCHIDA PHARM CO LTD (JP)
PUREC CO LTD (JP)
MOCHIDA PHARM CO LTD (JP)
International Classes:
A61K35/28; A61K31/734; A61K47/36; A61L27/20; A61L27/54; A61L27/58; A61P19/00; A61P43/00
Domestic Patent References:
| WO2017163603A1 | 2017-09-28 | |||
| WO2004076652A1 | 2004-09-10 | |||
| WO2016017795A1 | 2016-02-04 |
Foreign References:
| CN103013910A | 2013-04-03 |
Other References:
UKEBA DAISUKE, SUDO HIDEKI, TSUJIMOTO TAKERU, URA KATSURO, YAMADA KATSUHISA, IWASAKI NORIMASA: "Bone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs", EBIOMEDICINE, ELSEVIER BV, NL, vol. 53, 1 March 2020 (2020-03-01), NL , pages 102698, XP055955060, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2020.102698
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
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