Title:
COMPOSITION FOR TGR5 ACTIVATION
Document Type and Number:
WIPO Patent Application WO/2022/085602
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition that is for TGR5 activation and that contains, as an active ingredient, a substance that has a TGR5 activation effect and that shows a high selectivity for TGR5. The present invention pertains to a composition that is for TGR5 activation and that contains an extract of evening primrose seeds as an active ingredient.
Inventors:
FUNAKI AYUTA (JP)
Application Number:
PCT/JP2021/038334
Publication Date:
April 28, 2022
Filing Date:
October 18, 2021
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A61P3/04; A23K10/30; A23L33/105; A61K8/9789; A61K36/185; A61P3/10; A61P43/00; A61Q90/00; A61K131/00
Domestic Patent References:
| WO2002009734A1 | 2002-02-07 |
Foreign References:
| CN101574396A | 2009-11-11 | |||
| KR20030024745A | 2003-03-26 | |||
| KR102087033B1 | 2020-03-10 | |||
| KR101499457B1 | 2015-03-09 |
Other References:
AITANI MICHIO, NISHIMURA AKIRA, HAMADA KOICHIRO, KOBA TAKASHIGE, KONISHI YOTARO, GRADUATE: "The Effects of an Extract of Seeds of Evening Primrose on Postprandial Hyperglycemia on Human Subjects", NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, vol. 50, no. 10, 1 January 2003 (2003-01-01), pages 451 - 459, XP055924283
AITANI, KIMURA H, ABIRU Y, SOYAMA H, MURAKAMI H, ZHANG H.L, SUGISHITA T, KONISHI Y: "Effect of an extract from evening-primrose [Oenothera biennis L.] seeds on postprandial blood glucose level and its active components", JOURNAL OF JAPANESE SOCIETY OF FOOD SCIENCE AND TECHNOLOGY, NIPPON SHOKUHIN KAGAKU KOGAKUKAI, TSUKUBA, JP, vol. 50, no. 4, 1 April 2003 (2003-04-01), JP , pages 180 - 187, XP055924285, ISSN: 1341-027X, DOI: 10.3136/nskkk.50.180
JIELONG GUO, XUE HAN, HONGYU TAN, WEIDONG HUANG, YILIN YOU, JICHENG ZHAN: "Blueberry Extract Improves Obesity through Regulation of the Gut Microbiota and Bile Acids via Pathways Involving FXR and TGR5.", ISCIENCE, vol. 19, 27 September 2019 (2019-09-27), pages 676 - 690, XP055924286
HAN XUE, GUO JIELONG, YIN MANWEN, LIU YIWEN, YOU YILIN, ZHAN JICHENG, HUANG WEIDONG: "Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 64, no. 10, 1 May 2020 (2020-05-01), DE , pages 2000149, XP055924287, ISSN: 1613-4125, DOI: 10.1002/mnfr.202000149
ZHU YUE, ZHANG JIA-YING, WEI YU-LONG, HAO JING-YI, LEI YU-QING, ZHAO WAN-BIN, XIAO YU-HANG, SUN AI-DONG: "The polyphenol-rich extract from chokeberry (Aronia melanocarpa L.) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats", NUTRITION & METABOLISM, vol. 17, no. 1, 1 December 2020 (2020-12-01), XP055924288, DOI: 10.1186/s12986-020-00473-9
AITANI, KIMURA H, ABIRU Y, SOYAMA H, MURAKAMI H, ZHANG H.L, SUGISHITA T, KONISHI Y: "Effect of an extract from evening-primrose [Oenothera biennis L.] seeds on postprandial blood glucose level and its active components", JOURNAL OF JAPANESE SOCIETY OF FOOD SCIENCE AND TECHNOLOGY, NIPPON SHOKUHIN KAGAKU KOGAKUKAI, TSUKUBA, JP, vol. 50, no. 4, 1 April 2003 (2003-04-01), JP , pages 180 - 187, XP055924285, ISSN: 1341-027X, DOI: 10.3136/nskkk.50.180
JIELONG GUO, XUE HAN, HONGYU TAN, WEIDONG HUANG, YILIN YOU, JICHENG ZHAN: "Blueberry Extract Improves Obesity through Regulation of the Gut Microbiota and Bile Acids via Pathways Involving FXR and TGR5.", ISCIENCE, vol. 19, 27 September 2019 (2019-09-27), pages 676 - 690, XP055924286
HAN XUE, GUO JIELONG, YIN MANWEN, LIU YIWEN, YOU YILIN, ZHAN JICHENG, HUANG WEIDONG: "Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 64, no. 10, 1 May 2020 (2020-05-01), DE , pages 2000149, XP055924287, ISSN: 1613-4125, DOI: 10.1002/mnfr.202000149
ZHU YUE, ZHANG JIA-YING, WEI YU-LONG, HAO JING-YI, LEI YU-QING, ZHAO WAN-BIN, XIAO YU-HANG, SUN AI-DONG: "The polyphenol-rich extract from chokeberry (Aronia melanocarpa L.) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats", NUTRITION & METABOLISM, vol. 17, no. 1, 1 December 2020 (2020-12-01), XP055924288, DOI: 10.1186/s12986-020-00473-9
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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