Title:
COMPOSITION FOR TREATING INTERVERTEBRAL DISC
Document Type and Number:
WIPO Patent Application WO/2017/163603
Kind Code:
A1
Abstract:
The present invention provides a composition for replenishing the nucleus pulposus of an intervertebral disc, the composition containing a monovalent metal salt of a low endotoxin alginic acid. The composition is applied to a nucleus pulposus site of a subject, is used to harden a part after application, and has fluidity when applied to the nucleus pulposus site. Accordingly, a composition for replenishing nucleus pulposus is provided, the composition being capable of promoting the regeneration of the nucleus pulposus of an intervertebral disc.
Inventors:
SUDO HIDEKI (JP)
TSUJIMOTO TAKERU (JP)
IWASAKI NORIMASA (JP)
SHIMIZU SATOSHI (JP)
ISAJI MITSUKO (JP)
TSUJIMOTO TAKERU (JP)
IWASAKI NORIMASA (JP)
SHIMIZU SATOSHI (JP)
ISAJI MITSUKO (JP)
Application Number:
PCT/JP2017/002925
Publication Date:
September 28, 2017
Filing Date:
January 27, 2017
Export Citation:
Assignee:
NAT UNIV CORP HOKKAIDO UNIV (JP)
MOCHIDA PHARM CO LTD (JP)
MOCHIDA PHARM CO LTD (JP)
International Classes:
A61L27/20; A61K47/02; A61L26/00; A61P19/00; A61K31/734
Domestic Patent References:
| WO2008102855A1 | 2008-08-28 | |||
| WO2013027854A1 | 2013-02-28 | |||
| WO2006136905A2 | 2006-12-28 | |||
| WO2008102855A1 | 2008-08-28 | |||
| WO2013027854A1 | 2013-02-28 | |||
| WO1993013136A1 | 1993-07-08 |
Foreign References:
| JPH10503667A | 1998-04-07 | |||
| JP2008543449A | 2008-12-04 | |||
| US20070150060A1 | 2007-06-28 | |||
| US20070150060A1 | 2007-06-28 | |||
| US20030069639A1 | 2003-04-10 | |||
| US20090082719A1 | 2009-03-26 | |||
| JPH09324001A | 1997-12-16 | |||
| JPH08269102A | 1996-10-15 | |||
| JP2002530440A | 2002-09-17 | |||
| US5589591A | 1996-12-31 | |||
| JP2005036036A | 2005-02-10 |
Other References:
JOURNAL OF ANATOMY, vol. 221, 2012, pages 480 - 496
JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 7, 1989, pages 146 - 151
EUR SPINE J, vol. 16, 2007, pages 1892 - 1898
OSTEOARTHRITIS AND CARTILAGE, vol. 17, 2009, pages 1377 - 1384
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 29, 2014, pages 56 - 67
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 4, 2011, pages 1196 - 1205
ACTA BIOMATERIA, vol. 10, 2014, pages 1646 - 1662
SPINE J, vol. 13, no. 3, 2013, pages 243 - 262
MATERIALS SCIENCE AND ENGINEERING, vol. 63, 2016, pages 198 - 210
APPL. MICROBIOL. BIOTECHNOL., vol. 40, 1994, pages 638 - 643
.: "Japanese Pharmacopoeia, 16th ed.", .
SPINE (PHILA PA 1976, vol. 26, no. 17, 2001, pages 1873 - 8
SPINE (PHILA PA 1976, vol. 30, no. 1, 1 January 2005 (2005-01-01), pages 15 - 24
NISHIMURA ET AL., SPINE (PHILA PA 1976, vol. 23, no. 14, 1998, pages 1531 - 8
EUR SPINE J., vol. 23, no. 1, January 2014 (2014-01-01), pages 19 - 26
SPINE, vol. 27, no. 23, 2002, pages 2631 - 2644
EUR SPINE J., vol. 23, no. 1, 2014, pages 19 - 26
EUROPEAN CELLS AND MATERIALS, vol. 8, 2004, pages 58 - 64
WOESSNER JF JR, ARCH BIOCHEM BIOPHYS, vol. 93, 1961, pages 440 - 447
See also references of EP 3434291A4
JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 7, 1989, pages 146 - 151
EUR SPINE J, vol. 16, 2007, pages 1892 - 1898
OSTEOARTHRITIS AND CARTILAGE, vol. 17, 2009, pages 1377 - 1384
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 29, 2014, pages 56 - 67
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 4, 2011, pages 1196 - 1205
ACTA BIOMATERIA, vol. 10, 2014, pages 1646 - 1662
SPINE J, vol. 13, no. 3, 2013, pages 243 - 262
MATERIALS SCIENCE AND ENGINEERING, vol. 63, 2016, pages 198 - 210
APPL. MICROBIOL. BIOTECHNOL., vol. 40, 1994, pages 638 - 643
.: "Japanese Pharmacopoeia, 16th ed.", .
SPINE (PHILA PA 1976, vol. 26, no. 17, 2001, pages 1873 - 8
SPINE (PHILA PA 1976, vol. 30, no. 1, 1 January 2005 (2005-01-01), pages 15 - 24
NISHIMURA ET AL., SPINE (PHILA PA 1976, vol. 23, no. 14, 1998, pages 1531 - 8
EUR SPINE J., vol. 23, no. 1, January 2014 (2014-01-01), pages 19 - 26
SPINE, vol. 27, no. 23, 2002, pages 2631 - 2644
EUR SPINE J., vol. 23, no. 1, 2014, pages 19 - 26
EUROPEAN CELLS AND MATERIALS, vol. 8, 2004, pages 58 - 64
WOESSNER JF JR, ARCH BIOCHEM BIOPHYS, vol. 93, 1961, pages 440 - 447
See also references of EP 3434291A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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