COMPOSITION FOR TREATING OR PREVENTING LIVER CANCER.

WIPO Patent Application WO/2017/142283

A1

The present application relates to a pharmaceutical composition containing compound 5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]-4-3H)-quinazolinone, and a pharmaceutically acceptable salt thereof for preventing and treating liver cancer, and the composition of the present application inhibits ROS-PI3K-AKT-TERT signal transduction, and thus can be favorably used in the treatment of a liver cell cancer, in which a protein involved in the signal transduction is overexpressed, especially, advanced liver cell cancer.

JUNG GUHUNG (KR)
KO EUNKYONG (KR)
KIM YOON JUN (KR)

PCT/KR2017/001575

August 24, 2017

February 14, 2017

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UNIV SEOUL NAT R & DB FOUND (KR)

A61K31/52; A61K9/16; A61K9/20; A61K9/48; A61K31/517

WO2014051359A1

2014-04-03

KR101662975B1

2016-10-06

YANG, Q. ET AL.: "Idelalisib: First-in-class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma", CLINICAL CANCER RESEARCH, vol. 21, no. 7, 2015, pages 1537 - 1542, XP055305408
GEDALY, R. ET AL.: "The Role of P13K/mTOR Inhibition in Combination with Sorafenib in Hepatocellular Carcinoma Treatment", ANTICANCER RESEARCH, vol. 32, 2012, pages 2531 - 2536, XP055409681
HWANG, JU YEONG ET AL.: "Sanguinarine Induces Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells through the Generation of ROS and Modulation of Akt/ERK Signaling Pathways", JOURNAL OF SCIENCE, vol. 25, no. 9, 2015, pages 984 - 992, XP055411538

PARK, Weonmee (KR)

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