Title:
COMPOSITION FOR TREATING SPINAL CORD INJURY, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246642
Kind Code:
A1
Abstract:
Disclosed are a composition for treating spinal cord injury, a preparation method therefor and a use thereof. The composition comprises induced neural stem cells, fibrin and thrombin, and is particularly applicable for fully injured and fully transverse severe spinal cord injuries. The composition facilitates transplant operation, and transplanted cell loss is lower; the induced neural stem cells have high differentiation potential and are free of tumorigenicity, having a high differentiation ratio, a broad source and excellent safety.
Inventors:
CHEN ZHIGUO (CN)
LIU SUMEI (CN)
LIU SUMEI (CN)
Application Number:
PCT/CN2023/100707
Publication Date:
December 28, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
WISEHEART MEDICAL VALLEY CO LTD (CN)
International Classes:
A61K35/30; A61K47/42; A61L27/22; A61L27/38; A61L27/50; A61P25/00; C12N5/078; C12N5/0797
Foreign References:
| US20140308256A1 | 2014-10-16 | |||
| CN109526207A | 2019-03-26 | |||
| CN107405428A | 2017-11-28 | |||
| CN108137674A | 2018-06-08 | |||
| US20120308550A1 | 2012-12-06 | |||
| CN114984053A | 2022-09-02 |
Other References:
HONG, J. Y. ET AL.: "Therapeutic Potential of Induced Neural Stem Cells for Spinal Cord Injury", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 47, 21 November 2014 (2014-11-21), XP093120318
ROSENZWEIG EPHRON S, BROCK JOHN H, LU PAUL, KUMAMARU HIROMI, SALEGIO ERNESTO A, KADOYA KEN, WEBER JANET L, LIANG JUSTINE J, MOSEAN: "Restorative effects of human neural stem cell grafts on the primate spinal cord", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 24, no. 4, 1 April 2018 (2018-04-01), New York, pages 484 - 490, XP093120324, ISSN: 1078-8956, DOI: 10.1038/nm.4502
ROSENZWEIG EPHRON S, BROCK JOHN H, LU PAUL, KUMAMARU HIROMI, SALEGIO ERNESTO A, KADOYA KEN, WEBER JANET L, LIANG JUSTINE J, MOSEAN: "Restorative effects of human neural stem cell grafts on the primate spinal cord", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 24, no. 4, 1 April 2018 (2018-04-01), New York, pages 484 - 490, XP093120324, ISSN: 1078-8956, DOI: 10.1038/nm.4502
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
Download PDF: