Title:
COMPOSITION FOR USE IN PREVENTION OR TREATMENT OF MISCARRIAGE, PRE-ECLAMPSIA, AND IMMATURE FETUS, COMPRISING PECAM-1 ACTIVATING CATALYST AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2014/119833
Kind Code:
A1
Abstract:
The present invention relates to a composition for use in the prevention or treatment of miscarriage, pre-eclampsia, and an immature fetus, comprising a PECAM-1 activating catalyst as an active ingredient. The PECAM-1 activating catalyst according to the present invention increases regulatory T cells (Treg) in the mother, and markedly decreases miscarriage when animal models of miscarriage are treated with sCD38; thus, the catalyst can be useful as a prophylactic or therapeutic agent for miscarriage, pre-eclampsia, and an immature fetus.
Inventors:
KIM UH HYUN (KR)
KIM BYUNG JU (KR)
CHOI YOON MIN (KR)
RAH SO YOUNG (KR)
KIM BYUNG JU (KR)
CHOI YOON MIN (KR)
RAH SO YOUNG (KR)
Application Number:
PCT/KR2013/007549
Publication Date:
August 07, 2014
Filing Date:
August 22, 2013
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
A61K39/395; A61K38/16; A61K38/17; A61P15/00
Foreign References:
| US20050169920A1 | 2005-08-04 |
Other References:
A YASEMIN ET AL., ENDOCRINE, vol. 42, 2012, pages 125 - 131
accession no. DB 2EF1_A
E. GREYER ET AL., J. AMERICAN COLLEGE OF CARDIOLOGY, vol. 50, no. 4, 2007, pages 344 - 50
accession no. DB 2EF1_A
E. GREYER ET AL., J. AMERICAN COLLEGE OF CARDIOLOGY, vol. 50, no. 4, 2007, pages 344 - 50
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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