Title:
COMPOSITIONS OF ANTI-VIRAL PEPTIDES AND/OR COMPOUNDS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/083729
Kind Code:
A1
Abstract:
Broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting to viral resistance. The antiviral compositions are useful for treatment of diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A (H1N1) pdm09 virus, avian influenza A (H7N9) virus, and the non-enveloped rhinovirus.
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Inventors:
ZHAO HANJUN (CN)
YUEN KWOK-YUNG (CN)
YUEN KWOK-YUNG (CN)
Application Number:
PCT/CN2021/125649
Publication Date:
April 28, 2022
Filing Date:
October 22, 2021
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07K14/155; A61K35/76; A61P31/16; C12N15/86
Domestic Patent References:
| WO2019206285A1 | 2019-10-31 |
Foreign References:
| US20130280204A1 | 2013-10-24 | |||
| EP1959013A1 | 2008-08-20 | |||
| US20100029547A1 | 2010-02-04 |
Other References:
ZHAO HANJUN, TO KELVIN K. W., SZE KONG-HUNG, YUNG TIMOTHY TIN-MONG, BIAN MINGJIE, LAM HOIYAN, YEUNG MAN LUNG, LI CUN, CHU HIN, YUE: "A broad-spectrum virus- and host-targeting peptide against respiratory viruses including in fluenza virus and SARS-CoV-2", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), pages 1 - 10, XP055851420, DOI: 10.1038/s41467-020-17986-9
DWIGHT L. MCKEE, STERNBERG ARIANE, STANGE ULRIKE, LAUFER STEFAN, NAUJOKAT CORD: "Candidate drugs against SARS-CoV-2 and COVID-19", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 157, 1 January 2020 (2020-01-01), AMSTERDAM, NL, pages 104859, XP055693376, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2020.104859
ZHAO HANJUN, TO KELVIN K. W., LAM HOIYAN, ZHOU XINXIN, CHAN JASPER FUK-WOO, PENG ZHENG, LEE ANDREW C. Y., CAI JIANPIAO, CHAN WAN-M: "Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2", NATURE COMMUNICATIONS, vol. 12, no. 1, 1 December 2021 (2021-12-01), XP055924014, DOI: 10.1038/s41467-021-21825-w
DWIGHT L. MCKEE, STERNBERG ARIANE, STANGE ULRIKE, LAUFER STEFAN, NAUJOKAT CORD: "Candidate drugs against SARS-CoV-2 and COVID-19", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 157, 1 January 2020 (2020-01-01), AMSTERDAM, NL, pages 104859, XP055693376, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2020.104859
ZHAO HANJUN, TO KELVIN K. W., LAM HOIYAN, ZHOU XINXIN, CHAN JASPER FUK-WOO, PENG ZHENG, LEE ANDREW C. Y., CAI JIANPIAO, CHAN WAN-M: "Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2", NATURE COMMUNICATIONS, vol. 12, no. 1, 1 December 2021 (2021-12-01), XP055924014, DOI: 10.1038/s41467-021-21825-w
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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