Title:
COMPOSITIONS COMPRISING A SINGLE VARIABLE DOMAIN AND CAMOSTAT MESYLATE (CM)
Document Type and Number:
WIPO Patent Application WO/2014/030049
Kind Code:
A3
Abstract:
The present disclosure provides a means of stabilising a single variable domain, in particular in protease-rich environments such as the stomach and intestine. A composition, in particular a pharmaceutical composition, comprising a single variable domain and camostat mesylate is provided, together with uses of said composition as a medicament and in methods of treatment. Compositions of the disclosure are particularly useful in the topical treatment of gastrointestinal conditions, such as Crohn's Disease or ulcerative colitis, or for direct activity in the gut mucosal immune system.
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Inventors:
CLEVELAND SEAN MATTHEW (GB)
SALOMON STEFAN (GB)
VAN KRINKS CASSANDRA (GB)
SALOMON STEFAN (GB)
VAN KRINKS CASSANDRA (GB)
Application Number:
PCT/IB2013/001814
Publication Date:
April 17, 2014
Filing Date:
August 21, 2013
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
International Classes:
A61K39/00; A61K45/00
Other References:
TOZAKI HIDEYUKI ET AL: "Enhanced absorption of insulin and (Asu1,7)eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, WASHINGTON, US, vol. 90, no. 1, 1 January 2001 (2001-01-01), pages 89 - 97, XP002523315, ISSN: 0022-3549, [retrieved on 20001101], DOI: 10.1002/1520-6017(200101)90:1<89::AID-JPS10>3.0.CO;2-A
TOZAKI HIDEYUKI ET AL: "Use of Protease Inhibitors to Improve Calcitonin Absorption from the Small and Large Intestine in Rats", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 50, no. 9, 1 August 1998 (1998-08-01), pages 913 - 920, XP055099711, ISSN: 0022-3573
MARIA DORLY DEL CURTO ET AL: "Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 8, 1 August 2011 (2011-08-01), pages 3251 - 3259, XP055053312, ISSN: 0022-3549, DOI: 10.1002/jps.22560
MARIA DORLY DEL CURTO ET AL: "Preparation and evaluation of an oral delivery system for time-dependent colon release of insulin and selected protease inhibitor and absorption enhancer compounds", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 98, no. 12, 1 December 2009 (2009-12-01), pages 4661 - 4669, XP055053313, ISSN: 0022-3549, DOI: 10.1002/jps.21761
TOZAKI HIDEYUKI ET AL: "Use of Protease Inhibitors to Improve Calcitonin Absorption from the Small and Large Intestine in Rats", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 50, no. 9, 1 August 1998 (1998-08-01), pages 913 - 920, XP055099711, ISSN: 0022-3573
MARIA DORLY DEL CURTO ET AL: "Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 8, 1 August 2011 (2011-08-01), pages 3251 - 3259, XP055053312, ISSN: 0022-3549, DOI: 10.1002/jps.22560
MARIA DORLY DEL CURTO ET AL: "Preparation and evaluation of an oral delivery system for time-dependent colon release of insulin and selected protease inhibitor and absorption enhancer compounds", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 98, no. 12, 1 December 2009 (2009-12-01), pages 4661 - 4669, XP055053313, ISSN: 0022-3549, DOI: 10.1002/jps.21761
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