Title:
COMPOSITIONS CONTAINING LIPID MICRO- OR NANOPARTICLES FOR THE ENHANCEMENT OF THE DERMAL ACTION OF SOLID PARTICLES
Document Type and Number:
WIPO Patent Application WO/2010/051918
Kind Code:
A3
Abstract:
The invention is related to compositions which can be used as dermal formulations for supporting the skin to restore normal conditions in case of e.g. irritated skin, or to support medical therapy of skin with atopic dermatitis symptoms, atopic dermatitis, psoriasis or related diseases (e.g. accompanied by distorted barrier function of the skin and microbial load). The compositions of the invention can be used for dermo-cosmetic products but also for pharmaceutical/ - medical products, depending on the composition and the additional actives incorporated (cosmetic actives or drugs). The invention is based on the synergistic effect of metallic particles, in particular silver particles (such as microsilver, nanosilver) and lipid particles (lipid nanoparticles or lipid microparticles). As alternatives to silver particles, other metallic particles (e.g. zinc, copper) or nanocrystalline actives can be incorporated (e.g. replacing the anti -oxidative silver by anti -oxidative nanocrystals of plant molecules such as hesperitin). This leads to combinations of lipid particles with nanocrystals for dermal use.
Inventors:
KECK CORNELIA (DE)
Application Number:
PCT/EP2009/007645
Publication Date:
August 19, 2010
Filing Date:
October 26, 2009
Export Citation:
Assignee:
PHARMASOL GMBH (DE)
KECK CORNELIA (DE)
KECK CORNELIA (DE)
International Classes:
A61K9/51; A61K8/19; A61K33/24; A61K33/242; A61K33/243
Domestic Patent References:
| WO2008013785A2 | 2008-01-31 |
Foreign References:
| US6814959B1 | 2004-11-09 | |||
| US5188837A | 1993-02-23 |
Other References:
CENGIZ E ET AL: "Sunblocking efficiency of various TiO(2)-loaded solid lipid nanoparticle formulations(1).", INTERNATIONAL JOURNAL OF COSMETIC SCIENCE OCT 2006, vol. 28, no. 5, October 2006 (2006-10-01), pages 371 - 378, XP002550167, ISSN: 1468-2494
MULLER R H ET AL: "Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 50, no. 1, 3 July 2000 (2000-07-03), pages 161 - 177, XP004257186, ISSN: 0939-6411
MULLER R H ET AL: "Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 50, no. 1, 3 July 2000 (2000-07-03), pages 161 - 177, XP004257186, ISSN: 0939-6411
Attorney, Agent or Firm:
HEESCH, Helmut van et al. (Beselerstraße 4, Hamburg, DE)
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