Title:
COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPS), EPICARDIAL PROGENITOR CELLS (EPCS) AND MULTIPOTENT CXCR4+CD56+ CELLS (C56CS) AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2010/011352
Kind Code:
A3
Abstract:
The present invention relates to inter alia, methods for the generation and maintenance of Mesoderm-derived ISL 1+ Multipotent Progenitors (IMPs), the production of a number of pluripotent cells including and epicardial pluripotent cells (EPCs) and using these cells to produce endothelial cells, cardiomyocytes, smooth muscle cells, vascular cells and other cells and related methods as otherwise disclosed herein. The invention also relates to compositions comprising a population of cells.
Inventors:
DALTON STEPHEN (US)
REYNOLDS DAVID (US)
REYNOLDS DAVID (US)
Application Number:
PCT/US2009/004334
Publication Date:
May 06, 2010
Filing Date:
July 27, 2009
Export Citation:
Assignee:
UNIV GEORGIA (US)
DALTON STEPHEN (US)
REYNOLDS DAVID (US)
DALTON STEPHEN (US)
REYNOLDS DAVID (US)
International Classes:
C12N5/0775; A61K35/12; A61K35/28; A61K35/34; A61K35/545; C12N5/02
Domestic Patent References:
| WO2007070964A1 | 2007-06-28 |
Foreign References:
| US20060246446A1 | 2006-11-02 | |||
| US20060030042A1 | 2006-02-09 |
Other References:
YIBING QYANG ET AL.: "The renewal and differentiation of Isll+ cardiovascular progenitors are controlled by a Wnt/b-catenin pathway.", CELL STEM CELL., vol. 1, no. 2, August 2007 (2007-08-01), pages 165 - 179, XP009104129
ALESSANDRA MORETTI ET AL.: "Multipotent embryonic Isl 1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.", CELL., vol. 127, no. 6, December 2006 (2006-12-01), pages 1151 - 1165, XP008143594
REBECCA STEWART ET AL.: "Mechanisms of self-renewal in human embryonic stem cells.", EUROPEAN JOURNAL OF CANCER., vol. 42, no. 9, June 2006 (2006-06-01), pages 1257 - 1272, XP025104768
ALESSANDRA MORETTI ET AL.: "Multipotent embryonic Isl 1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.", CELL., vol. 127, no. 6, December 2006 (2006-12-01), pages 1151 - 1165, XP008143594
REBECCA STEWART ET AL.: "Mechanisms of self-renewal in human embryonic stem cells.", EUROPEAN JOURNAL OF CANCER., vol. 42, no. 9, June 2006 (2006-06-01), pages 1257 - 1272, XP025104768
Attorney, Agent or Firm:
COLEMAN, Henry, D. (P.C.714 Colorado Avenu, Bridgeport CT, US)
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