Title:
COMPOSITIONS AND METHODS FOR THE ACCELERATION OF PROTEIN SECRETION DYNAMICS
Document Type and Number:
WIPO Patent Application WO2003088916
Kind Code:
A3
Abstract:
The present invention provides compositions and methods for modulating the secretion of transcriptionally regulated proteins from recombinant cells. More particularly, the present invention provides compositions and methods for accelerating the secretion dynamics of human insulin from recombinant cells using nonsense mediated mRNA decay of preproinsulin mRNA transcript.
Inventors:
TANG SHIU-CHENG (US)
SAMBANIS ATHANASSIOS (US)
SAMBANIS ATHANASSIOS (US)
Application Number:
PCT/US2003/012228
Publication Date:
November 11, 2004
Filing Date:
April 21, 2003
Export Citation:
Assignee:
GEORGIA TECH RES INST (US)
TANG SHIU-CHENG (US)
SAMBANIS ATHANASSIOS (US)
TANG SHIU-CHENG (US)
SAMBANIS ATHANASSIOS (US)
International Classes:
C07K14/62; C12N15/63; (IPC1-7): C12P19/34; C12Q1/68; C12N5/00; C12N5/06; C12N15/63; C12N15/87; A01N43/04; C07H21/02; C07H21/04
Other References:
TANG S.C. ET AL: "Preproinsulin mRNA engineering and its application to the regulation of insulin secretion from human hepatomas", FEBS LETTERS, vol. 537, no. 1-3, 27 February 2003 (2003-02-27), pages 193 - 197, XP004412003
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