Title:
COMPOSITIONS AND METHODS COMPRISING WEST NILE VIRUS POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO2002072036
Kind Code:
A3
Abstract:
This application is directed to compositions and methods comprising isolated and purified West Nile virus polypeptides and immunogenic fragments thereof, nucleic acid molecules encoding them and antibodies specific for such polypeptides or fragments. Such polypeptides and fragments, fusion proteins comprising them and antibodies are useful as vaccines to treat, inhibit or prevent West Nile virus infection or disease, to detect West Nile virus infection and to monitor the course of disease or immunization.
Inventors:
FIKRIG EROL (US)
KOSKI RAYMOND A (US)
WANG TIAN (US)
KOSKI RAYMOND A (US)
WANG TIAN (US)
Application Number:
PCT/US2002/009036
Publication Date:
May 22, 2003
Filing Date:
March 11, 2002
Export Citation:
Assignee:
UNIV YALE (US)
L2 DIAGNOSTICS LLC (US)
FIKRIG EROL (US)
KOSKI RAYMOND A (US)
WANG TIAN (US)
L2 DIAGNOSTICS LLC (US)
FIKRIG EROL (US)
KOSKI RAYMOND A (US)
WANG TIAN (US)
International Classes:
C07K14/18; C12N15/33; C12P21/08; (IPC1-7): A61K39/12
Foreign References:
| US5494671A | 1996-02-27 | |||
| US5486473A | 1996-01-23 |
Other References:
WANG ET AL.: "West Nile virus envelope protein: role in diagnosis and immunity", ANNALS NEW YORK ACADEMY OF SCIENCE, vol. 951, December 2001 (2001-12-01), pages 325 - 327, XP002961137
WANG ET AL.: "Immunization of mice against West Nile virus with recombinant envelope protein", JOURNAL OF IMMUNOLOGY, vol. 167, 2001, pages 5273 - 5277, XP002961138
KRAMER ET AL.: "West Nile virus in the Western hemisphere", CURRENT OPINION IN INFECTIOUS DISEASES, vol. 14, 2001, pages 519 - 525, XP002961139
MATHEWS ET AL.: "T-helper cell and associated antibody response to synthetic peptides of the E glycoprotein of Murray Valley encephalitis virus", JOURNAL OF VIROLOGY, vol. 65, no. 10, October 1991 (1991-10-01), pages 5141 - 5148, XP002961140
LANCIOTTI ET AL.: "Origin of the West Nile virus responsible for an outbreak of encephalitis in the Northeastern United States", SCIENCE, vol. 286, 17 December 1999 (1999-12-17), pages 2333 - 2337, XP002198957
ANDERSON ET AL.: "Isolation of West Nile virus from mosquitoes, crows and a Cooper's hawk in Connecticut", SCIENCE, vol. 286, 17 December 1999 (1999-12-17), pages 2331 - 2333, XP002191030
PRICE ET AL.: "Live and inactivated vaccines of group B arboviruses: role of neutralizing antibody and serum protective factor", NATURE, vol. 222, 1969, pages 1294 - 1295, XP002961141
WANG ET AL.: "Immunization of mice against West Nile virus with recombinant envelope protein", JOURNAL OF IMMUNOLOGY, vol. 167, 2001, pages 5273 - 5277, XP002961138
KRAMER ET AL.: "West Nile virus in the Western hemisphere", CURRENT OPINION IN INFECTIOUS DISEASES, vol. 14, 2001, pages 519 - 525, XP002961139
MATHEWS ET AL.: "T-helper cell and associated antibody response to synthetic peptides of the E glycoprotein of Murray Valley encephalitis virus", JOURNAL OF VIROLOGY, vol. 65, no. 10, October 1991 (1991-10-01), pages 5141 - 5148, XP002961140
LANCIOTTI ET AL.: "Origin of the West Nile virus responsible for an outbreak of encephalitis in the Northeastern United States", SCIENCE, vol. 286, 17 December 1999 (1999-12-17), pages 2333 - 2337, XP002198957
ANDERSON ET AL.: "Isolation of West Nile virus from mosquitoes, crows and a Cooper's hawk in Connecticut", SCIENCE, vol. 286, 17 December 1999 (1999-12-17), pages 2331 - 2333, XP002191030
PRICE ET AL.: "Live and inactivated vaccines of group B arboviruses: role of neutralizing antibody and serum protective factor", NATURE, vol. 222, 1969, pages 1294 - 1295, XP002961141
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