Title:
COMPOSITIONS AND METHODS FOR CORONAVIRUS DETECTION
Document Type and Number:
WIPO Patent Application WO/2021/222772
Kind Code:
A3
Abstract:
Disclosed herein, are recombinant polypeptides comprising a first domain, wherein the first domain comprises an epitope of a coronavirus or wherein the first domain is a moiety that is capable of specifically binding a coronavirus antigen; a linker; and a second domain, wherein the second domain is a moiety that is capable of specifically binding an antigen on the surface of a red blood cell. Also, disclosed herein are methods for detecting anti-coronavirus antibodies, one or more coronavirus antigens, or one or more coronavirus virions by mixing the recombinant polypeptide with red blood cells and anti-coronavirus antibodies resulting in visible agglutination.
Inventors:
KRUSE ROBERT (US)
HUANG YUTING (US)
WANG ZACK (US)
HUANG YUTING (US)
WANG ZACK (US)
Application Number:
PCT/US2021/030212
Publication Date:
December 02, 2021
Filing Date:
April 30, 2021
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
C07K14/165; A61P31/12; C07K14/08; C07K19/00
Domestic Patent References:
| WO2013121296A1 | 2013-08-22 | |||
| WO2008124086A2 | 2008-10-16 |
Foreign References:
| US20060257852A1 | 2006-11-16 | |||
| US20050255470A1 | 2005-11-17 |
Other References:
DATABASE Nucleotide ANONYMOUS: "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome", XP055831365, retrieved from NCBI Database accession no. MN908947
Attorney, Agent or Firm:
KLIEM, Michele, A. et al. (US)
Download PDF: