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Title:
COMPOSITIONS AND METHODS FOR DECREASING INFLAMMATION
Document Type and Number:
WIPO Patent Application WO/2022/036229
Kind Code:
A3
Abstract:
The present invention features bifunctional, soluble ecto-enzymes that are engineered to hydrolyze extracellular nucleotide triphosphates (e.g., ATP) to a nucleoside (e.g., adenosine), through the fusion of the ectodomains (ECD) of an ecto-nucleoside triphosphate diphosphohydrolase (E- NTPDase) and a nucleotide monophosphatase (NMPAse), such as an ecto-5' nucleotidase (eN), alkaline phosphatase (ALP), or an acid phosphatase (AP). Also described are methods of use thereof, e.g. for limiting and decreasing inflammation and sequelae.

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Inventors:
ROBSON SIMON (US)
ZHONG ELIZABETH (US)
Application Number:
PCT/US2021/045956
Publication Date:
April 21, 2022
Filing Date:
August 13, 2021
Export Citation:
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Assignee:
BETH ISRAEL DEACONESS MEDICAL CT INC (US)
International Classes:
C12N9/14; A61K38/46; C12N9/16
Foreign References:
US20150190481A12015-07-09
US20050037382A12005-02-17
Attorney, Agent or Firm:
ARMSTRONG, Richard, Todd (US)
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