Title:
COMPOSITIONS AND METHODS FOR DELIVERY AND PRODUCTION OF ANTIBODIES USING AN RNA-CONTAINING NANOPARTICLE PLATFORM
Document Type and Number:
WIPO Patent Application WO/2023/121960
Kind Code:
A3
Abstract:
Embodiments of the instant disclosure relate to novel complexes, compositions, and methods for generating and delivering antibodies to induce a pathway in a subject. Other embodiments relate to generating antibodies for treating a health condition or inducing a pathway for inducing a cellular immune response to treat a health condition. In accordance with these embodiments, nanoparticle complexes disclosed herein include antibody-encoding mRNA transcripts, encapsulated into a lipid nanoparticle. In other embodiments, complexes disclosed herein can be administered to a subject in combination with administration of a vaccine to a subject.
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Inventors:
KEDL ROSS (US)
HESSELBERTH JAY (US)
FLEMING IRA (US)
WILLETT BENJAMIN (US)
HESSELBERTH JAY (US)
FLEMING IRA (US)
WILLETT BENJAMIN (US)
Application Number:
PCT/US2022/053132
Publication Date:
August 31, 2023
Filing Date:
December 16, 2022
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
International Classes:
C07K16/18; A61K39/395; C07K16/28; C07K16/32
Foreign References:
| EP0896585A1 | 1999-02-17 |
Other References:
MORITZ THRAN ET AL: "mRNA mediates passive vaccination against infectious agents, toxins, and tumors", EMBO MOLECULAR MEDICINE (ONLINE), vol. 9, no. 10, 9 August 2017 (2017-08-09), DE, pages 1434 - 1447, XP055505303, ISSN: 1757-4684, DOI: 10.15252/emmm.201707678
RYBAKOVA YULIA ET AL: "mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo", MOLECULAR THERAPY, vol. 27, no. 8, 1 August 2019 (2019-08-01), US, pages 1415 - 1423, XP055832159, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2019.05.012
DEAL CAILIN E. ET AL: "Advancements in mRNA Encoded Antibodies for Passive Immunotherapy", VACCINES, vol. 9, no. 2, 31 January 2021 (2021-01-31), pages 108, XP055936813, DOI: 10.3390/vaccines9020108
BUSCHMANN MICHAEL D. ET AL: "Nanomaterial Delivery Systems for mRNA Vaccines", VACCINES, vol. 9, no. 1, 1 January 2021 (2021-01-01), CH, pages 65, XP055927791, ISSN: 2076-393X, DOI: 10.3390/vaccines9010065
ÁLVAREZ-BENEDICTO ESTER ET AL: "Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)", BIOMATERIALS SCIENCE, vol. 10, no. 2, 18 January 2022 (2022-01-18), GB, pages 549 - 559, XP093025758, ISSN: 2047-4830, DOI: 10.1039/D1BM01454D
RYBAKOVA YULIA ET AL: "mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo", MOLECULAR THERAPY, vol. 27, no. 8, 1 August 2019 (2019-08-01), US, pages 1415 - 1423, XP055832159, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2019.05.012
DEAL CAILIN E. ET AL: "Advancements in mRNA Encoded Antibodies for Passive Immunotherapy", VACCINES, vol. 9, no. 2, 31 January 2021 (2021-01-31), pages 108, XP055936813, DOI: 10.3390/vaccines9020108
BUSCHMANN MICHAEL D. ET AL: "Nanomaterial Delivery Systems for mRNA Vaccines", VACCINES, vol. 9, no. 1, 1 January 2021 (2021-01-01), CH, pages 65, XP055927791, ISSN: 2076-393X, DOI: 10.3390/vaccines9010065
ÁLVAREZ-BENEDICTO ESTER ET AL: "Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)", BIOMATERIALS SCIENCE, vol. 10, no. 2, 18 January 2022 (2022-01-18), GB, pages 549 - 559, XP093025758, ISSN: 2047-4830, DOI: 10.1039/D1BM01454D
Attorney, Agent or Firm:
HANSON, Roberta J. et al. (US)
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