COMPOSITIONS AND METHODS FOR DOUBLE-TARGETING VIRUS INFECTIONS AND TARGETING CANCER CELLS

WIPO Patent Application WO2001034614

A3

The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions of the invention include compounds which comprise a phosphocholine moiety covalently conjugated with one or more antiviral agents (e.g. nucleoside analogue, protease inhibitor, etc.) to a lipid backbone. The invention also includes pharmaceutical compositions and kits for use in treatment of a virus infection in mammals. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to treat the infection, to a mammal infected with a virus. Additionally, the invention includes compositions and methods useful for combating a cancer in a mammal and for facilitating delivery of a therapeutic agent to a mammalian cell. The compositions of of the invention include compounds which comprise an alkyl lipid or phospholipid moiety covalently conjugated with an anticancer agent (e.g. a nucleoside analogue). The invention also includes pharmaceutical compositions and kits for combating a cancer and for facilitating delivery of a therapeutic agent to a mammalian cell. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to combat a cancer or to facilitate delivery of a therapeutic agent to a mammalian cell.

WO/2014/016740	IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE
JP3071448	Description: Heterocyclic Substituted Sulfonyl Ureas, Methods of Their Production and Their Use as Herbicides or Plant Growth Regulators
WO/1987/006837	ANTIBODY CONJUGATES OF AMINE DERIVATIVES OF FOLIC ACID ANALOGS

KUCERA LOUIS S (US)
FLEMING RONALD A (US)
ISHAQ KHALID S (US)
KUCERA GREGORY L (US)
MORRIS-NATSCHKE SUSAN L (US)

PCT/US2000/041352

December 27, 2001

October 20, 2000

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UNIV WAKE FOREST (US)
UNIV NORTH CAROLINA (US)
KUCERA LOUIS S (US)
FLEMING RONALD A (US)
ISHAQ KHALID S (US)
KUCERA GREGORY L (US)
MORRIS NATSCHKE SUSAN L (US)

C07D475/08; A61K31/519; A61K31/66; A61K31/661; A61K31/675; A61K31/7068; A61K45/00; A61P1/16; A61P9/00; A61P13/12; A61P25/00; A61P31/12; A61P31/18; A61P31/22; A61P35/00; A61P35/02; C07F9/09; C07F9/10; C07F9/165; C07H19/06; C07H19/10; C07H19/16; (IPC1-7): C07H19/06; A61K31/685; A61K31/7052; A61P31/12; A61P35/00; C07F9/10; C07H19/16

WO1988003146A1	1988-05-05
WO1991019726A1	1991-12-26
WO1996006620A2	1996-03-07

PIANTADOSI C ET AL: "SYNTHESIS AND EVALUATION OF NOVEL ETHER LIPID NUCLEOSIDE CONJUGATES FOR ANTI-HIV-1 ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 34, no. 4, 1991, pages 1408 - 1414, XP002000878, ISSN: 0022-2623
HONG C I ET AL: "FORMULATION, STABILITY, AND ANTITUMOR ACTIVITY OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE CONJUGATE OF THIOETHER PHOSPHOLIPID", CANCER RESEARCH,US,AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 50, no. 14, 15 July 1990 (1990-07-15), pages 4401 - 4406, XP000571731, ISSN: 0008-5472

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